← brief for 2026-08-17 · Slowing decline

Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model.

Key takeaways

In rats bred to have kidney disease, a drug called PDSinh-C01 lowered salt-driven high blood pressure and corrected acid buildup in the blood. The drug blocks a kidney protein called pendrin. This was done in animals, not people yet. It is an early sign the target may be worth testing.

Who did this work

Rudolphi CF · Goos Y · Musterd-Bhaggoe U · van Veghel R · Garrelds IM · Danser AHJ · Karmakar J · Cil O · Imenez Silva PH · Hoorn EJ

Source

Article · PubMed, CKD nutrition RCTs · 2026 Aug 17
https://pubmed.ncbi.nlm.nih.gov/42606602/