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Epigenetic inactivation of COL4A4 orchestrates JAK2/STAT3-driven progression and microenvironment reprogramming in renal cell carcinoma

Paper D Peer reviewed Preclinical

Key takeaways

This study used kidney organoids (mini-kidneys grown from stem cells) to show how gene silencing affects cancer progression. It covers epigenetic inactivation of COL4A4 and its impact on tumor microenvironment.

Who did this work

Hanxi Zhou · Xiong Tian · Zhenyu Yang · Chuanjing Dai · Jingmin Zheng

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-18
https://doi.org/10.1016/j.intimp.2026.117305