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Ubiquitin-Specific Protease 11 Promotes Uric Acid-Induced Renal Tubular Epithelial Cell Apoptosis via Deubiquitinating P53 and Enhancing Mitochondrial Outer Membrane Permeabilization

Paper D Peer reviewed Preclinical

Key takeaways

This study used kidney cells to show how ubiquitin-specific protease 11 promotes cell death via p53 and mitochondrial damage. It covers the role of uric acid in kidney injury.

Who did this work

Yingfeng Shi (Shanghai East Hospital) · Jinqing Li (Shanghai East Hospital) · Na Liu (Shanghai East Hospital)

Source

Paper · OpenAlex, CKD works · 2026-08-18
https://doi.org/10.3390/biomedicines14081852