Kidney research, 2026-08-20
New insights on aging markers and vascular calcification in kidney disease
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A review discusses targeting smooth muscle cells to prevent arterial calcification
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A study on older kidney transplant recipients shows potential long-term benefit despite early risk
Today's coverage includes new findings on aging markers and vascular calcification. We also look at the debate over using AI to detect acute kidney injury in hospital patients.
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
A trial of finenorme in children with CKD and proteinuria. The study will enroll 50 patients over 18 months.
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
A trial of twice-weekly vs. thrice-weekly dialysis in veterans with kidney disease. The study will enroll 252 Veterans over 3 years.
Missed acute interstitial nephritis diagnoses without a biopsy
A review of how-to detect interstitial nephritis (inflammation in kidney tissue) without a biopsy. The authors find that using biomarkers and ultrasound may help detect this...
Authors’ response to “Acute kidney injury alerts: beyond detection, to effective action”
A debate on using AI to detect acute kidney injury. The study uses different models for each kidney segment.
Reconsidering segment-specific Klotho regulation in renal mineral homeostasis
A debate on mineral handling in the kidney. The study uses different models for each kidney segment.
Beyond observation: genetic evidence linking Ruminococcus B gnavus and Egerieenecus merdigallinarum to kidney function traits
An observational study links gut bacteria to kidney health. The findings suggest a link between the microbiome and early kidney damage.
Authors’ response to “Circulating engagement or intrarenal action in signal regulatory protein α–engineered mesenchymal stem cell–derived extracellular vesicle therapy for acute kidney injury?”
A debate on whether engineered EVs work via blood cells or direct kidney action. The-s_m_p_k_t_r_e_f_c_ a: better model for kidney injury in African American patients. The study...
Corrigendum to “ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.” Kidney International 2024;106:419–432
A correction for a study on vascular function in the kidney. The original paper had switched group images.
New ideas about mechanism in APOL1 kidney disease
A new study proposes a specific mechanism for kidney injury in African American patients. The findings suggest the risk is linked to mitochondrial dysfunction and differ from...
The Case | When the diagnosis is more than skin deep
A woman with vasculitis (inflammation of blood vessels) was treated with prednisone, dapsone, and mycophenolate. She had kidney injury from the vasculitis but no-one knows if she...
No staining needed: reading kidney injury by its own light
The study used near-infrared autofluorescence to detect kidney injury in mice and humans. This method detects mitochondrial oxidative stress without using fluorescent labels. It...
Can MQ232 guide to novel options for treatment of ADPKD?
The study used MQ232 in mice with polycystic kidney disease (PKD). The drug slowed cyst growth but worked differently in males and females. It may offer new options for PKD...
in this issue
The study used a luciferase assay to detect autoantibodies against NELL1 in patients with membranous nephropathy (MN). This method could help identify MN cases that standard assays...
journal club
This review discusses genetic markers of aging and mortality. It covers multiple-organ aging processes.
Toward multilevel therapeutic targeting of medial arterial calcification in chronic kidney disease
This review discusses targeting vascular smooth muscle cells to prevent calcification. It covers multiple targets in kidney disease patients.