← brief for 2026-09-09 · Nutrition & lifestyle

Perspectives on the Nutritional Paradox in Uremia: A "Sensitize-Then-Feed" Framework for Protein-Energy Wasting.

Key takeaways

People with advanced kidney disease often lose muscle and weight, a problem called protein-energy wasting. This paper says that simply adding more calories and protein often does not fix it, because the body stops responding to food normally. The authors propose treating the underlying inflammation first, then feeding, which they call sensitize-then-feed. It is a proposed framework, not a trial, so there are no results showing it works.

Who did this work

Li M · Chen Z · Liu N · Lan N · Zeng F · Xue C · Yang B

Source

Article · PubMed, Nutritional supplements and CKD · 2026 Sep 9
https://pubmed.ncbi.nlm.nih.gov/42716437/