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Single genetic trigger model of CKD-associated cardiac remodeling in podocyte-specific MafB knockout mice

Key takeaways

This study used mice with a specific gene change to mimic kidney disease. The mice developed heart changes that match human kidney disease. This was in animals, not people yet. It helps scientists understand how kidneys affect the heart.

Who did this work

Mitsunori Fujino (University of Tsukuba) · Shun Ishibashi (University of Tsukuba) · Walaa A. Basha (Suez Canal University) · Kazuya Murata (University of Tsukuba) · Hideki Yokoi (Kumamoto University) · Masato Kasahara (Nara Medical University Hospital) · Masami Ojima (University of Tsukuba) · Satoru Takahashi (University of Tsukuba)

Source

Article · OpenAlex, CKD works · 2026-09-17
https://doi.org/10.1038/s41598-026-69773-z