← brief for 2026-09-17 · Slowing decline

Targeting DPP9 attenuates podocyte injury by regulating NRF2 antioxidant signaling

Key takeaways

This study examined how a drug called finerenone protects kidney cells from damage. It found that the drug works by reducing stress in the cells. This research was done in cells and tissues, not in people yet, so it explains the mechanism behind the drug's effect.

Who did this work

Chenkai Cui (Second Affiliated Hospital of Xi'an Jiaotong University) · Shizhuo Wei (Second Affiliated Hospital of Xi'an Jiaotong University) · Jianpeng Zhang (Second Affiliated Hospital of Xi'an Jiaotong University) · Jing Xu (Second Affiliated Hospital of Xi'an Jiaotong University) · Shokhida Naimova (Bukhara State Medical Institute named after Abu Ali ibn Sino) · Yan Li (Second Affiliated Hospital of Xi'an Jiaotong University) · Haodong Wang (Second Affiliated Hospital of Xi'an Jiaotong University) · Yinhong Wang (Second Affiliated Hospital of Xi'an Jiaotong University) · Ruoyan Si (Second Affiliated Hospital of Xi'an Jiaotong University) · Linting Wei (Second Affiliated Hospital of Xi'an Jiaotong University) · Fuqian Lei (Second Affiliated Hospital of Xi'an Jiaotong University) · Xiaoyong Yu (Shaanxi Provincial Hospital of Traditional Chinese Medicine)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-17
https://doi.org/10.3389/fphar.2026.1930044