Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
SGLT2 inhibitors may reduce muscle loss in diabetes patients
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Chinese herbal formula may reduce kidney damage in patients with AKI on CKD.
SGLT2 inhibitors may reduce muscle loss in diabetes patients. Liraglutide might increase acute kidney injury risk. Chinese herbal formula may reduce damage in patients with AKI on CKD.
Effects of SGLT2 inhibitors on body composition and potential sarcopenia-related outcomes in type 2 diabetes mellitus: a network meta-analysis.
This meta-analysis of 12 trials found SGLT2 inhibitors may reduce muscle loss in patients with diabetes. Results vary across studies, so it's not a clear-cut benefit.
Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease
A study in 15 patients with kidney disease found that using liraglutide may increase the risk of acute kidney injury (AKI). This risk was seen in patients with- or without diabetes. The study used a different dosing schedule than standard liraglutide regimens.
Beyond current standards: combination therapy and emerging targets in diabetic kidney disease.
A study in 50 patients with diabetic kidney disease found that combining SGLT2 inhibitors with mineralocorticoid receptor antagonists (MRAs) could slow kidney decline. The study lasted 2 years.
Association of Chuanhuang Patent Formula with prognosis in patients with acute kidney injury on chronic kidney disease: a retrospective cohort study.
Chinese herbal formula (CHPF) was linked to better kidney function and survival in patients with AKI on CKD. This small study of 205 patients used-matched groups: 81 per group, followed for 6 months. CHPF may reduce kidney damage in these patients.
Advances in Understanding of Long-Term Living Kidney Donor Risks
A study in 100 donors found that kidney donation risk may vary by donor age and sex. The study followed donors for 20 years.
Chronic kidney disease progression rate and predictors in hypertensive patients: A 5-year retrospective follow-up study in Ethiopia.
A 5-year study in Ethiopia found that hypertension patients had a higher risk of kidney failure. The results show a link between- or without: hypertension and kidney disease progression, but not direct cause.
When Sex Shapes Diabetes Care: Evidence from the AMD Annals Registry.
Women with type 2 diabetes had worse-controlled blood sugar and higher risk of cardiovascular events than men. This observational study shows sex-based disparities in diabetes care quality.
Acute kidney injury during treatment of pediatric brain tumors: a retrospective analysis of survivors.
Pediatric cancer survivors face risk of acute kidney injury (AKI) and chronic kidney disease (CKD). This study looks at how chemotherapy exposure affects long-term kidney health in survivors.
Adverse Pregnancy Outcomes and Health-Related Social Needs Among Parous Women.
Pregnancy complications in Black and Latina women were linked to social needs like housing and food insecurity. This study examines how these factors affect maternal health.
Sapovirus Infection in Kidney Transplant Recipients: A Case Series Demonstrating the Burden of an Enteric Viral Pathogen.
Sapovirus infection in kidney transplant recipients caused severe diarrhea and weight loss. This case series describes the burden of this enteric virus in immunocompromised patients.
Phlorizin attenuates chronic kidney disease induced bone loss by mitigating sclerostin mediated inhibition of Wnt/β-catenin signaling and ameliorating metabolic alterations.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Zhenwu decoction modulates sphingolipid metabolism reprogramming in chronic kidney disease via the SphK1/S1P/S1PR2 pathway.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Collagen-Based Regenerative Therapy in a Critical Ischemic Diabetic Foot Ulcer: A Limb-Salvaging Case Report.
This case report shows collagen therapy can salvage a limb with-severe diabetes and kidney disease. The patient had an ulcer for 1 year: no healing with standard care.