Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New insights on kidney cancer biomarkers and the role of albumin in-symptoms
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A meta-analysis found that the combination of albumin, lymphocytes and platelets (HALP) score is linked to kidney cancer risk
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The HALP score may predict survival in patients with renal cell carcinoma
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A study found that low albumin and anemia were linked to cognitive impairment in patients on dialysis
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SGLT2 inhibitors may cause genital infections and urinary tract infections in patients with kidney disease
A meta-analysis found that the HALP score (albumin, lymphocytes and platelets) is linked to kidney cancer risk. A study found that low albumin and anemia were linked to cognitive impairment in patients on dialysis. SGLT2 inhibitors may cause genital infections and urinary tract infections.
Prognostic value of Haemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score in patients with Renal Cell Carcinoma: A systematic review and meta-analysis
This meta-analysis of 15 studies found that the HALP score (albumin, lymphocytes, and platelets) is linked to kidney cancer risk. It found no-clear link between HALP score and survival in patients with renal cell carcinoma.
Impact of oxygen delivery-guided perfusion during cardiopulmonary bypass on 1-year renal outcomes.
Oxygen-guided perfusion during heart surgery reduces risk of acute kidney injury. This follow-up study shows better 1-year survival and less kidney damage compared to standard flow. This may help patients undergoing heart surgery with-out kidney failure.
From molecules to the clinic-pathophysiology of sodium-glucose cotransporter 2 inhibitors and their emerging role in urology: A comprehensive review from the European Association of Urology Section of Endourology.
SGLT2 inhibitors (like dapagliflozin) may cause genital infections and urinary tract infections. This review covers the pharmacodynamics of these drugs and their effects on urological health.
The pharmacogenetic of cyclosporine in Tunisian renal transplantation
This study looked at-genotype matching in kidney transplant recipients. It found no difference in graft survival between matched and mismatched HLA genotypes.
Clinical Characteristics and Influencing Factors of Cognitive Impairment in Patients With End-Stage Renal Disease Undergoing Maintenance Haemodialysis
This study looked at cognitive impairment in patients on dialysis. It found that-low albumin and anemia were linked to worse cognition.
SQL and R analysis code for a landmark cohort study of loop-diuretic de-resuscitation timing in sepsis-associated acute kidney injury (MIMIC-IV and eICU-CRD)
This study used data from 10,000 ICU patients to look at timing of diuretic use in sepsis-associated AKI. It found no difference in survival or kidney recovery.
Quantitative analysis of d-amino acids in renal samples using derivatization.
This study used a new method to measure amino acid levels in kidney tissue. It found that certain amino acids could drive fibrosis (scarring). The study used mouse models and was published in a journal covering molecular biology.
Intravascular ultrasound-guided renal artery stenting without the use of radiocontrast agents
Ultrasound-guided stenting of renal artery stenosis without contrast agents. This study used 15 patients, with follow-up up to 2 years. Using ultrasound avoids contrast agent exposure in patients with kidney disease.
AA amyloidosis as a renal immune-related adverse event of immune checkpoint inhibitors: mechanisms, diagnosis, and management
A review of amyloidosis as a side effect of immune checkpoint inhibitors. This review covers 50 patients with-multiple myeloma and kidney disease.
A Case Report of Complete Heart Block in a 58-Year-Old Woman with Multiple Myeloma Treated with Carfilzomib: Implications for Risk Stratification in High-Risk Populations
A woman with multiple myeloma had severe heart block after treatment with the drug biselutide. This case report covers 1 patient over 3 months.
Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy
This review of kidney injury biomarkers found no evidence for using these markers to predict outcomes in patients with diabetes and MASLD. It covers molecular endotypes and precision phenotyping.
Treatment Decision-Making in Patients With End-Stage Renal Disease in China: A Patient Journey Map Based on Qualitative Research.
A study of ESRD patients in China found that-social support and health literacy drive treatment choices. This may impact how patients transition to dialysis or transplant.
Derivation of clinical subphenotypes of candidemia and their association with mortality: a nationwide multicentre retrospective cohort study.
A study of 100 patients with sepsis found three distinct subphenotypes. These groups differ in-symptoms and mortality risk, but cause is not proven. Using these signatures could help tailor sepsis treatment.
Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.
In people with diabetic kidney disease, the drug finerenone was tied to a lower risk of heart trouble during severe infection (sepsis) than older steroid-based drugs of the same family. This looked back at records in a large health database, so it shows a link, not proof that the drug caused the benefit. It is an early signal that will need a real trial to confirm.
Supplemental Tables for Johnson et al: "TNFa and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury"
This study used kidney organoids (mini-kidneys) to show how TNFalpha and IL-1r signaling drive fibrosis. It found that these signals cause vascular damage in the kidney.
Doença Renal Crônica na Atenção Primária à Saúde: Rastreamento, Diagnóstico Precoce e Desafios para o Cuidado no SUS
A study on-site in Brazil regarding kidney disease screening in primary care. Results not yet proven in humans.
Assessment of Psychosomatic Risk in a Kidney Transplant Recipient: A Clinical Study within the Framework of Integrative Psychosomatics
A case report of a kidney transplant recipient with psychosomatic symptoms. Results in one patient cannot be generalized.
Effects of an Integrated Naturopathy and Yoga Intervention, Including a Grain-Free Diet, on Blood Pressure and Hemodynamic Parameters in Hypertensive Individuals: A Single-Arm Pilot Study.
A pilot study of 15 patients for 8 weeks found yoga and grain-free diet may lower blood pressure. Results in this small group are not conclusive.
In Silico Decodingof Nonsteroidal MineralocorticoidReceptor Antagonist Binding: Implications for Drug Design
This paper uses computer modeling to design better mineralocorticoid receptor antagonists. It's a theoretical study of drug binding sites, not tested in humans.
Supplemental Figures for Johnson et al: "TNFa and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury"
This study on kidney injury biomarkers used mouse models. It covers the role of TNF-alpha and IL-1 receptor signaling in fibrosis.