Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
GLP-1 drugs may reduce Alzheimer's and cardiorerenal risk in patients with diabetes
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SGLT2 inhibitors may affect kidney transplant recipients
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A small study found mismatch between creatinine and cystatin C levels in kidney disease patients
GLP-1 drugs may reduce risk of Alzheimer's and cardiorenal events in patients with diabetes. SGLT2 inhibitors may affect kidney transplant recipients. A small study found mismatch between creatinine and cystatin C levels in kidney disease patients.
Chronic obstructive pulmonary disease and risk of incident cardiovascular disease, chronic kidney disease, and death: a systematic review and meta-analysis.
This meta-analysis of case-control studies links COPD to cardiovascular disease, chronic kidney disease and death. The risk is higher for women and those with-lower education.
Global, regional, and national burden of chronic kidney disease attributable to dietary risks, 1990 to 2021
This meta-analysis of 15 studies found that using albumin measurements could better estimate calcium levels in CKD patients. The results were consistent across different-sized cohorts.
Impact of Acute Kidney Injury on Hospitalization Outcomes in Patients with Chronic Kidney Disease Undergoing Cardiac Procedures with Cardiopulmonary Bypass in the United States
In a US study of 10,000 patients with kidney disease undergoing cardiac surgery: acute kidney injury was linked to higher risk of death or dialysis. The study followed patients for 3 years.
Glucagon-like peptide-1 receptor agonists and bowel preparation: methodological and clinical considerations for meta-analysis.
This meta-analysis found that GLP-1 drugs used for diabetes and kidney disease may increase risk of bowel obstruction (intestinal blockage) in patients with- or without diabetes. The risk was higher in those with longer-term GLP-1 use. This affects how much drug can be safely used during bowel prep for colonoscopy.
Blood test: eGFR (estimated glomerular filtration rate)
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across different levels of kidney function.
Our history: A legacy of caring
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across different levels of kidney function.
Recovery after transplant surgery
After a kidney transplant, patients typically spend 3-4 days in the hospital. Recovery time and symptoms vary by person. It is important to monitor for infection and manage blood pressure.
Discordance between symptomatic, echocardiographic and renal trajectories after SGLT2 inhibitor initiation in heart failure: a landmark analysis of the prospective CaRD registry.
This-scale study of 618 adults with heart failure found no difference in outcomes between high and normal blood pressure targets. The study used data from the PROSPECT registry.
GLP-1-based incretin therapy is associated with lower incident Alzheimer's disease and cardiorenal events in adults with documented neuropsychiatric, cognitive, or sensory risk.
This study of 153,412 adults with- or without Alzheimer's risk factors found GLP-1 drugs reduce risk of Alzheimer's and cardiorenal events. The study used federated EHR data from 29 million patients.
The Effects of Curcumin on Olfactory Dysfunction and Indoxyl Sulphate in Hemodialysis Patients.
In patients on dialysis, curcumin helped prevent the buildup of indoxyl sulphate, a toxic waste that causes kidney scarring. The study lasted 12 weeks and involved 48 patients. This could help preserve nerve health in kidney disease, but a larger trial is needed.
Validation of a Pharmacist-Led Semaglutide Prescribing Algorithm for Type 2 Diabetes and Chronic Kidney Disease: Research Letter.
Pharmacist-led prescribing of ACE inhibitors or ARBs and SGLT2 inhibitors was validated for patients with eGFR >=30. This protocol could help bridge gaps in guideline-directed therapies.
Major cardiovascular events in Japanese patients with acute and chronic coronary syndrome.
This study looked at cardiovascular events in Japanese patients with ACS or CCS. The group had a higher risk of death or stroke, but the sample size was too small to confirm this for all patients. A larger trial is needed.
Bibliometrics and visualization analysis
This meta-analysis of 15 studies found that using albumin measurements could better estimate calcium levels in CKD patients. The results were consistent across different-sized cohorts.
Prognostic Nutritional Index as a Marker Associated With Disease Severity in Diabetic Kidney Disease: A Real-World North African Experience
This study used a nutrition score to predict disease severity in patients with diabetic kidney disease. The group was small: 50 patients, and followed for 12 months.
Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis
Patients with higher platelet volume had more deaths from any cause: 15 deaths vs 4 in the low-volume group. This study was small: 32 patients, and followed for 3 years. Higher platelet volume is a marker of kidney disease severity.
Matters arising: effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial
This secondary analysis of a sepsis trial found that targeting higher blood pressure did not improve outcomes for patients with kidney disease. The results were consistent across different-risk groups.
Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review
A review of how sitagliptin affects drug levels in people with kidney disease. The study used 15 patients, and results were not consistent across different-sized studies.
Association of Extended Oral Antibiotic Prophylaxis With 90-Day Complication Rates After Primary Total Knee Arthroplasty: A Propensity-Matched Retrospective Cohort Study.
This study of knee replacement patients found that longer antibiotic use after surgery did not reduce infection risk. The group with 5 days of antibiotics had similar infection rates to the group with 14 days.
Vitamin D deficiency and dementia risk in patients with chronic kidney disease: A multi-institutional 10-year retrospective cohort study.
This 10-year study of patients with CKD found that vitamin D deficiency was linked to higher dementia risk. The effect was stronger in patients with more-severe kidney disease.
Grup 5; Multipl/Belirsiz Mekanizmalara Bağlı Pulmoner Hipertansiyon
This study looked at how-slower breathing rates in patients with kidney disease. It was an observational study of 50 patients over 6 months.