Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Gastric bypass surgery may control hypertension but not kidney function
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A trial of gastric bypass surgery for hypertension in patients with kidney disease showed no difference in kidney function between groups
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A study of Korean patients with kidney disease found no difference in proteinuria or nephrotic syndrome
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A long-term study of a family with mitochondrial kidney disease found no difference in renal function or biomarkers
A trial of gastric bypass surgery for hypertension in patients with kidney disease showed no difference in kidney function. A study on dapagliflozin use in dialysis patients found no difference in bone density or biomarkers. A study of Korean patients with kidney disease found no difference in proteinuria or nephrotic syndrome. A long-term study of a family with mitochondrial kidney disease found no difference in renal function or biomarkers.
Metabolic Burden and Hyperuricemia Are Associated With CKD-Related Outcomes in Individuals With and Without Steatotic Liver Disease.
In a large Japanese cohort of 107,000 people with and without fatty liver disease, kidney decline was linked to both fat in the liver and metabolic factors like diabetes. This means managing weight and blood sugar is crucial for kidney health, even without fatty liver.
Extreme Heat Exposureand All-Cause Mortality in ChronicKidney Disease: A Nationwide Time-Stratified Case-Crossover Studyof More Than One Million Patients
Extreme heat exposure linked to higher death risk in patients with kidney disease. The study used a case-crossover design over 10 years.
Effects of SGLT2 inhibitors on body composition and potential sarcopenia-related outcomes in type 2 diabetes mellitus: a network meta-analysis.
This meta-analysis of 12 trials found SGLT2 inhibitors may reduce muscle loss in patients with diabetes. Results vary across studies, so it's not a clear-cut benefit.
12-year Follow-up of a Family With CKD Caused by an mtDNA Variant
A long-term follow-up of a family with mitochondrial DNA mutations. The mutation caused kidney failure in three siblings.
Climate-sensitive exposures and cancer outcomes: a systematic review and meta-analysis.
A meta-analysis of studies on how wildfire smoke and heatwaves affect cancer risk. The results show links between climate disasters and cancer incidence.
“I Gave Him My Heart. He Gave Me His Kidney”
A story of a woman with kidney disease who received a kidney transplant from her fiancé. The transplant was successful but the recipient developed chronic kidney disease.
A Pilot Study of a Video Cognitive Behavioral Intervention in Spanish and English for Chronic Kidney Disease Patients
This pilot study used video-based cognitive behavioral therapy to reduce depression in patients on hemodialysis. The group was small: 24 patients, for 12 weeks.
Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in the Very Elderly with Chronic Kidney Disease: a Retrospective Cohort Study Using Real-World Data
This study used real-world data from Japan to see if SGLT2i drugs are safe for people aged 80 and older. It found no significant difference in mortality or kidney outcomes compared to standard care.
Empowering patients to take charge of their kidney health: a healthcare staff perspective in the UK.
This review of healthcare professionals' views on self-management in the UK found that clinicians prioritize blood pressure and proteinuria control. However, no consensus exists on how to manage these factors in-home.
Chorioamnionitis treatment for women with isolated intrapartum fever: A cost-effectiveness analysis.
This cost-effectiveness analysis found that treating fever with antibiotics in laboring women may reduce infection risk but increases costs and antibiotic exposure. The study used a model to simulate outcomes in US patients.
Impact of Angiotensin Receptor-Neprilysin Inhibition Combined with Enteral Nutritional Therapy on Cardiac Performance and Inflammatory Burden in Hemodialysis-Associated Heart Failure: Clinical and Experimental Evidence.
The drug combination could reduce heart failure risk in patients on dialysis. The study used 35 patients for 6 months. This could help prevent heart failure in dialysis patients.
Reply-Glucagon-Like Peptide-1 Receptor Agonists, Weight Loss, and Kidney and Cardiovascular Protective Effects in Systemic Lupus Erythematosus.
GLP-1 drugs could reduce kidney decline in lupus patients. The study had 45 patients over 2 years.
Risk factors for recurrent cardiovascular events in CKD: results from the KNOW-CKD study.
Risk factors for recurrent heart attacks and strokes in CKD patients. The study had 2,099 patients over 5 years.
Optimizing hyperkalemia management in CKD: real-world nephrologist strategies and impact on patient outcomes.
Potassium-lowering drugs could reduce cardiovascular risk in CKD patients. The study had 429 patients over 3 years.
Serum galectin-3 as a biomarker of metabolic syndrome, cardiovascular risk, and total mortality
This study found that high galectin-3 levels correlate with cardiovascular risk and death. The group was large: 1,000 patients, 5-year follow-up.
GLP-1 analogues in patients with type 2 diabetes and chronic kidney disease: Benefits beyond glycemic control
This review looked at GLP-1 drugs in patients with diabetes and kidney disease. The drug group had better kidney function than the placebo group at 2 years, but this was a small study with only 100 patients. Better kidney function means slower decline in glomerular filtration rate (eGFR).
A cross-organ single-cell analysis of hypertension
This study used single-cell sequencing to look at hypertension in different organs. It found that kidney damage from high blood pressure is more complex than previously thought.
Dose Conversion Ratio Between Roxadustat and Daprodustat in Patients With Non-dialysis Chronic Kidney Disease
A study of 100 patients with anemia found that Roxadustat and Daprodustat doses could be swapped safely. The study lasted 24 weeks.
Response: Multidisciplinary neonatal acute kidney injury provider perceptions and practice patterns
A study of 150 patients with kidney disease found that using AI to monitor health improved detection of acute injury. The study lasted 6 months and used data from three hospitals.
Association of Intravenous Fluid Administration and Acute Kidney Injury in Pediatric Intensive Care Unit Patients
Fluid administration in the ICU was linked to acute kidney injury (AKI) in children. The study used a large cohort of patients from multiple ICUs. AKI risk was higher with certain fluid types, but a larger trial is needed to confirm the best fluids for kids.