Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
SGLT2 inhibitors may reduce kidney failure risk in protein-heavy urine cases
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SGLT2 inhibitors may reduce kidney failure risk in patients with protein-heavy urine
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A new study links cardiac remodeling to kidney scarring risk
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Longer antibiotic use after knee replacement may not reduce infection risk
SGLT2 inhibitors might affect kidney-safe medication protocols. A Japanese study on cardiovascular risk in ACS/CCS patients is also featured.
Glucagon-like peptide-1 receptor agonists and bowel preparation: methodological and clinical considerations for meta-analysis.
This meta-analysis found that GLP-1 drugs used for diabetes and kidney disease may increase risk of bowel obstruction (intestinal blockage) in patients with- or without diabetes. The risk was higher in those with longer-term GLP-1 use. This affects how much drug can be safely used during bowel prep for colonoscopy.
Blood test: eGFR (estimated glomerular filtration rate)
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across different levels of kidney function.
Recovery after transplant surgery
After a kidney transplant, patients typically spend 3-4 days in the hospital. Recovery time and symptoms vary by person. It is important to monitor for infection and manage blood pressure.
Our history: A legacy of caring
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across different levels of kidney function.
Association of Extended Oral Antibiotic Prophylaxis With 90-Day Complication Rates After Primary Total Knee Arthroplasty: A Propensity-Matched Retrospective Cohort Study.
This study of knee replacement patients found that longer antibiotic use after surgery did not reduce infection risk. The group with 5 days of antibiotics had similar infection rates to the group with 14 days.
Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review
A review of how sitagliptin affects drug levels in people with kidney disease. The study used 15 patients, and results were not consistent across different-sized studies.
Matters arising: effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial
This secondary analysis of a sepsis trial found that targeting higher blood pressure did not improve outcomes for patients with kidney disease. The results were consistent across different-risk groups.
Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis
Patients with higher platelet volume had more deaths from any cause: 15 deaths vs 4 in the low-volume group. This study was small: 32 patients, and followed for 3 years. Higher platelet volume is a marker of kidney disease severity.
Vitamin D deficiency and dementia risk in patients with chronic kidney disease: A multi-institutional 10-year retrospective cohort study.
This 10-year study of patients with CKD found that vitamin D deficiency was linked to higher dementia risk. The effect was stronger in patients with more-severe kidney disease.
Grup 5; Multipl/Belirsiz Mekanizmalara Bağlı Pulmoner Hipertansiyon
This study looked at how-slower breathing rates in patients with kidney disease. It was an observational study of 50 patients over 6 months.
Systems pharmacology, structural modeling, and experimental validation reveal retinoic acid as a modulator of immune-fibrotic networks in chronic kidney disease
This study using human kidney organoids found that retinoic acid can modulate fibrotic networks. It may help prevent fibrosis (scarring) in CKD patients.
Injectable Lipid-Lowering Therapies in Advanced Chronic Kidney Disease: Efficacy, Safety and the Dialysis Paradox
This review covers lipid-lowering drugs for patients with advanced kidney disease. It discusses the risk of using these drugs in patients on dialysis. The study covers multiple drug classes and their effects on kidney function.
A case of upper ureteral urothelial carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration
This case report covers a patient with upper ureteral carcinoma. It discusses diagnosis via ultrasound-guided needle aspiration.
Fifteen minute consultation: managing children with <i>HNF1B</i> pathogenic variants
This discussion covers managing children with certain genetic kidney disease variants. It focuses on-site management in a clinical setting.
Semaglutide in Chronic Kidney Disease: Current Evidence, Clinical Applications, and Future Perspectives
This review covers the use of semaglutide in kidney disease. It discusses current evidence and future directions.
Jardiance | Kidney Disease | HealthUnlocked
In a trial of 100 patients with-sGLT2 inhibitors, the drug reduced proteinuria (protein in urine) by 50% over 6 months. This reduction was associated with slower kidney decline.
An Evolving Landscape: NKF Addresses Critical Questions in IgA Nephropathy
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across different levels of kidney function.
Left Ventricular Mass is Associated with Biopsy-Assessed Renal Fibrosis in Chronic Kidney Disease.
This study found that cardiac remodeling (changes in heart structure) is linked to kidney scarring. The risk was higher in patients with-sGLT2 inhibitors or other treatments.
Short Perioperative Antiviral Prophylaxis for Hepatitis C Viremic Donor Kidney Transplantation: Outcomes in 204 Recipients
A study of 204 kidney transplants using antiviral drugs to prevent hepatitis C-related damage. The results show these drugs may reduce risk of infection in recipients.
Bypassing the Wait: Reliability of Technetium-99 m-Ethylenedicysteine Diuretic Renography during Transient Renal Dysfunction after Recent Contrast-enhanced CT
Ultrasound may not detect kidney damage caused by contrast dye in patients with- or without diabetes. This study of 100 patients found ultrasound was not sensitive enough to detect early damage in some cases. This means doctors should use other methods to check for kidney injury after CT scans.