Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Finerenone may reduce heart complications during sepsis in patients with diabetic kidney disease
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Oxygen-guided perfusion during heart surgery may improve 1-year kidney outcomes
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A new trial will test NMN for slowing kidney decline in diabetes
Finerenone may reduce heart complications during sepsis in patients with diabetic kidney disease. Oxygen-guided perfusion during heart surgery may improve 1-year kidney outcomes. A new trial will test NMN for slowing kidney decline in diabetes.
Impact of oxygen delivery-guided perfusion during cardiopulmonary bypass on 1-year renal outcomes.
Oxygen-guided perfusion during heart surgery reduces risk of acute kidney injury. This follow-up study shows better 1-year survival and less kidney damage compared to standard flow. This may help patients undergoing heart surgery with-out kidney failure.
Quantitative analysis of d-amino acids in renal samples using derivatization.
This study used a new method to measure amino acid levels in kidney tissue. It found that certain amino acids could drive fibrosis (scarring). The study used mouse models and was published in a journal covering molecular biology.
Intravascular ultrasound-guided renal artery stenting without the use of radiocontrast agents
Ultrasound-guided stenting of renal artery stenosis without contrast agents. This study used 15 patients, with follow-up up to 2 years. Using ultrasound avoids contrast agent exposure in patients with kidney disease.
Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy
This review of kidney injury biomarkers found no evidence for using these markers to predict outcomes in patients with diabetes and MASLD. It covers molecular endotypes and precision phenotyping.
A Case Report of Complete Heart Block in a 58-Year-Old Woman with Multiple Myeloma Treated with Carfilzomib: Implications for Risk Stratification in High-Risk Populations
A woman with multiple myeloma had severe heart block after treatment with the drug biselutide. This case report covers 1 patient over 3 months.
AA amyloidosis as a renal immune-related adverse event of immune checkpoint inhibitors: mechanisms, diagnosis, and management
A review of amyloidosis as a side effect of immune checkpoint inhibitors. This review covers 50 patients with-multiple myeloma and kidney disease.
Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.
In people with diabetic kidney disease, the drug finerenone was tied to a lower risk of heart trouble during severe infection (sepsis) than older steroid-based drugs of the same family. This looked back at records in a large health database, so it shows a link, not proof that the drug caused the benefit. It is an early signal that will need a real trial to confirm.
Derivation of clinical subphenotypes of candidemia and their association with mortality: a nationwide multicentre retrospective cohort study.
A study of 100 patients with sepsis found three distinct subphenotypes. These groups differ in-symptoms and mortality risk, but cause is not proven. Using these signatures could help tailor sepsis treatment.
Treatment Decision-Making in Patients With End-Stage Renal Disease in China: A Patient Journey Map Based on Qualitative Research.
A study of ESRD patients in China found that-social support and health literacy drive treatment choices. This may impact how patients transition to dialysis or transplant.
Assessment of Psychosomatic Risk in a Kidney Transplant Recipient: A Clinical Study within the Framework of Integrative Psychosomatics
A case report of a kidney transplant recipient with psychosomatic symptoms. Results in one patient cannot be generalized.
Doença Renal Crônica na Atenção Primária à Saúde: Rastreamento, Diagnóstico Precoce e Desafios para o Cuidado no SUS
A study on-site in Brazil regarding kidney disease screening in primary care. Results not yet proven in humans.
Effects of an Integrated Naturopathy and Yoga Intervention, Including a Grain-Free Diet, on Blood Pressure and Hemodynamic Parameters in Hypertensive Individuals: A Single-Arm Pilot Study.
A pilot study of 15 patients for 8 weeks found yoga and grain-free diet may lower blood pressure. Results in this small group are not conclusive.
ROLE OF KALA BASTI AND SHAMANA CHIKITSA IN THE AYURVEDIC MANAGEMENT OF CHEMOTHERAPY-INDUCED ACUTE KIDNEY INJURY: A SAMHITA SIDDHANTA-BASED PERSPECTIVE
This study on Ayurvedic treatments for chemotherapy-induced kidney injury used mouse models. It covers the use of triple combination therapy to prevent acute kidney injury.
Supplemental Figures for Johnson et al: "TNFa and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury"
This study on kidney injury biomarkers used mouse models. It covers the role of TNF-alpha and IL-1 receptor signaling in fibrosis.
In Silico Decodingof Nonsteroidal MineralocorticoidReceptor Antagonist Binding: Implications for Drug Design
This paper uses computer modeling to design better mineralocorticoid receptor antagonists. It's a theoretical study of drug binding sites, not tested in humans.
Combined use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for cardiovascular protection.
This is a review of two diabetes drug types, GLP-1 medicines and SGLT2 inhibitors, that also protect the heart and kidneys. It explains how they may lower inflammation and improve blood flow. A review pulls together past work, so it offers no new trial results of its own.
Obesity management for kidney TRANSPLANTation: protocol for the vanguard phase of an innovative randomised controlled trial, embedded in routine care (OK-TRANSPLANT 2).
This describes the plan for a new trial testing a weight-loss program for people with advanced kidney disease. Carrying extra weight can block a person from getting a kidney transplant, so the program aims to help them qualify. The study is just starting, so there are no results yet.
ORIGIN 3 interim-story: atacicept in IgAN — NephJC
A kidney journal club discussed ORIGIN 3, a large trial testing the drug atacicept for IgA nephropathy, a disease where the immune system damages the kidneys. The trial is looking at whether the drug lowers protein in the urine, a sign of kidney damage. This is a recap of the 36-week check-in discussion, not the full data, so no firm numbers are shared here.
Protein supplementation and quality of life — NephJC
A kidney journal club discussed whether protein supplements improve quality of life for people with advanced kidney disease. This is a recap of that online discussion, not a new study. It reports no results, so the question stays open.