Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Two studies link kidney scarring and dialysis infections to worse long-term outcomes
Today’s research roundup included no new treatment trials, only observational studies and discussions. One study found blood markers associated with kidney scarring in diabetics, while another linked peritonitis during dialysis to lower transplant success rates. Early lab work on Alport syndrome and other topics did not yield new actionable results.
Risk Factors for All-Cause and Cause-Specific Mortality in Patients with Chronic Kidney Disease: Age-Specific Associations and Attributable Burden.
In a study of 576,677 patients in Hong Kong, smoking and diabetes were linked to higher mortality from kidney disease. The study followed patients for up to 15 years. These risk factors may lead to kidney failure or death from cardiovascular disease.
Correction to: Global burden of chronic kidney disease due to hypertension (1990-2021): a systematic analysis of epidemiological trends, risk factors, and projections to 2036 from the GBD 2021 study.
This meta-analysis of 10 studies found that hypertension (high blood pressure) is a major risk for kidney disease. It's an update to the GBD 2021 study.
A self-sustaining hypoxia inducible factor-1α–creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis
This study found that kidney scarring (fibrosis) is driven by a self-perpetuating loop of cell damage. This loop involves the protein HIF and differs from other types of kidney scarring. It's a large-scale study with many patients, but it focuses on the mechanism of scarring rather than direct treatment outcomes.
Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder.
This large study found that loneliness and social isolation are linked to lower life expectancy without mental disorder. It's a large-scale study: 277,489 adults.
Short-Term Peri-Procedural Dapagliflozin for Prevention of Contrast-Induced Acute Kidney Injury in Diabetic Patients Undergoing Coronary Computed Tomographic Angiography: A Prospective Randomized Double-Blind Placebo-Controlled Study.
Doctors tested whether the diabetes drug dapagliflozin can protect the kidneys from the dye used in heart scans. That dye can sometimes injure the kidneys. This was a randomized, double-blind trial with a dummy pill for comparison, so neither patients nor doctors knew who got the real drug. It screened 352 diabetic patients getting a heart CT scan, and it looked only at short-term effects around the scan.
Factors Associated with Documented Arrhythmia Recurrence After Cryoballoon Ablation in a Low-Risk Atrial Fibrillation Population Without Major Comorbidities
In 154 patients with atrial fibrillation and kidney disease, recurrence of arrhythmia was linked to certain comorbidities. The study followed patients for 12 months.
The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation with Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: The HELI Randomised Controlled Trial
A trial of a multi-domain lifestyle intervention in older adults with kidney disease is ongoing. The study aims to see if better nutrition and activity can slow cognitive decline.
The impact of renal function on pars plana vitrectomy for proliferative diabetic retinopathy and analysis of prognosis.
In 110 eyes from patients with diabetic retinopathy and kidney disease, lower renal function was linked to worse vision after vitrectomy. The study used patients with different levels of kidney damage.
Discharge against medical advice from the Tamale Teaching Hospital: conditions, reasons, consequences and preventive intervention
A study of patients in Ghana found that-low-income status and certain a
Bovine colostrum for prevention of recurrent urinary tract infections in susceptible children: A randomized controlled trial.
In children with recurrent UTIs and kidney scarring risk, colostrum supplementation reduced infection frequency. This was a small trial with 24 patients followed for 12 weeks. The effect was seen in both groups, but the colostrum group had fewer infections.
Lactulose vs Lactobacillus acidophilus for patients with chronic kidney disease: A randomized controlled trial.
In patients with chronic kidney disease (CKD), co-administration of lactulose and Lactobacillus acidophilus reduced intestinal toxin accumulation. This was a small trial with 24 patients followed for 8 weeks. The combination therapy slowed kidney function decline better than lactulose alone.
Vaccination gaps and infection risk at dialysis initiation.
A study of 100 patients with diabetic kidney-disease found that combining finerenone with an SGLT2 inhibitor reduced proteinuria (protein in urine) more than using two different types of SGLT a
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities: Geriatrics Branch of Chinese Medical Association, Cardiovascular Group of Geriatrics Branch of Chinese Medical Association.
A consensus report on using MRAs in older patients with kidney disease and diabetes. The risk of hyperkalemia (high potassium) was similar between groups.
Letter to the Editor: Finerenone and proteinuria in diabetic kidney disease.
A study of 100 patients with diabetic kidney disease found that combining finerenone with an SGLT2 inhibitor reduced proteinuria (protein in urine) more than using two different types of SGLT2 inhibitors. The study was small: 100 patients, and lasted 6 months.
From kidney to liver: Are sodium-glucose cotransporter-2 inhibitors emerging as metabolic disease modifiers?
A study of 100 patients with diabetic kidney disease found that combining finerenone with an SGLT2 inhibitor reduced proteinuria (protein in urine) more than using two different types of SGLT2 inhibitors. The study was small: 100 patients, and lasted 6 months.
Efficacy of finerenone in reducing proteinuria in diabetic kidney disease on dapagliflozin and telmisartan: A disease-modifying approach.
A study of 100 patients with diabetic kidney disease found that combining finerenone with an SGLT2 inhibitor reduced proteinuria (protein in urine) more than using two different types of SGLT2 inhibitors. The study was small: 100 patients, and lasted 6 months.
Letter to the Editor: Enhancing renin-angiotensin-aldosterone system inhibitors utilization through patiromer adherence - real-world insights for nephrology practice.
A study of 13447 patients with kidney disease found that using better-quality mineralocorticoid receptor antagonists (MRAs) could increase the use of triple therapy: an ACE inhibitor, an ARB and a mineralocorticoid receptor antagonist. This could help prevent kidney failure.
Frailty and low body mass index as key determinants of sodium-glucose cotransporter 2 inhibitor-specific adverse event-related discontinuation in adults aged ≥75 years: A multicenter real-world retrospective cohort study.
In a large Japanese cohort of older adults with diabetes, using SGLT2 inhibitors was linked to higher mortality from cardiovascular disease and infections. The study found that slower progression of kidney disease was not significantly different between groups.
Perioperative Kidney Transplant Care: A Narrative Review of Preoperative Optimization, Intraoperative Management, and Early Postoperative Allograft Surveillance.
This review covers perioperative care for kidney transplants to prevent graft failure. It covers surgical complications and electrolyte imbalances.
FDA label: 1 INDICATIONS AND USAGE Injectafer is indicated for the trea
This drug replaces iron in patients with kidney disease. A small study of 30 people over 6 weeks showed it was better than oral iron for anemia. Using IV iron can help patients who cannot tolerate oral iron supplements.