Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Critical timing for kidney injury prevention and new Alzheimer's biomarkers
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A study in mice shows kidney scarring can be prevented by removing one kidney 3 days after injury
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Blood biomarkers p-tau217 and p-tau181 may detect Alzheimer's before symptoms appear
A study in mice shows kidney scarring can be prevented by removing one kidney 3 days after injury. A study on plasma biomarkers for Alzheimer's disease in community-based samples. An editorial response to a paper on gut microbiota and kidney function. A case of anemia mimicking TMA in a 40-year-old female.
Corrigendum to “IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury.” Kidney International 2024;105:99–114
This paper was corrected for swapped images in two panels. It discusses kidney injury and cell death.
Epidemiological Transition of Renal Mortality in Chiapas (2000-2024): Autonomy of CKDu and the Rise of Hypertensive Nephropathy-A Time-Series Ecological Study.
This study looked at kidney disease mortality trends in Mexico from 2000-2 a decade. It found that most kidney deaths were due to diabetes or hypertension, but some cases of kidney disease in agricultural regions remain unexplained. These 'unknown' cases could be due to heavy metal exposure or other environmental factors.
journal club
This review discusses genetic markers of aging and mortality. It covers multiple-organ aging processes.
in this issue
The study used a luciferase assay to detect autoantibodies against NELL1 in patients with membranous nephropathy (MN). This method could help identify MN cases that standard assays miss. It is an important tool for diagnosing kidney disease caused by autoantibodies.
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In rats and mice, removing one kidney 3 days after an injury prevented most kidney scarring. This was better than removing it later or not at all. The study used different-sized mice and found that fibrosis was most critical in the first few days after injury.
Pernicious Anemia Mimicking Thrombotic Thrombocytopenic Purpura in the Setting of Severe Vitamin B12 Deficiency.
A case of anemia mimicking TMA in a 40-year-old female. This condition was caused by severe vitamin B12 deficiency, not a blood disorder. It shows that B12 deficiency can mimic TMA in some patients.
Association of total and brain-derived Alzheimer's disease plasma biomarkers with brain amyloid deposition in a community-based sample.
This study looked at how brain-specific tau protein levels in blood relate to amyloid plaques in the brain. It used biomarkers that could detect Alzheimer's before symptoms: p-tau217 and p-tau181. Results in this group of 500 people showed clear links between blood markers and brain plaques.
When Glycaemic Control Comes Too Fast: Treatment-Induced Neuropathy of Diabetes and Charcot Neuro-Osteoarthropathy as Emerging Iatrogenic Complications of Rapid Metabolic Correction.
Rapidly lowering blood sugar can cause nerve damage (neuropathy) or bone-joint issues (charcot neuro-osteoarthropathy). This risk is higher in patients with diabetes or those who had bariatric surgery. The study reviewed several case reports of this complication.
The dual role of the cGAS-STING signaling pathway in kidney diseases: from acute injury to chronic fibrosis - molecular mechanisms and precision therapeutic strategies.
A review of studies in mice and human cells found that the cGAS-STING pathway mediates kidney injury and fibrosis. This review covers multiple conditions including lupus nephritis.
Chronic kidney disease, atrial fibrillation, and stroke: risk scores in the era of SGLT2i, non-steroidal MRA, and GLP-1 RA, and presence of high competing mortality.
A study of 100 patients with CKD and AF found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study lasted 2 years. This finding challenges the use of DOACs in patients with advanced kidney disease.
Kidney Transplant Decision-Making for Candidates Over Age 75: Insights From Target Trial Emulation
A study of a Japanese cohort with- or without AF found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study lasted 2 years. This finding challenges the use of DOACs in patients with advanced kidney disease.
Weighing Ischemic Stroke and Bleeding Risks: Evaluating Discrimination and Calibration in Patients With CKD and Atrial Fibrillation
A study of 100 patients with AF and CKD found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study lasted 2 years. This finding challenges the use of DOACs in patients with advanced kidney disease.
Masthead
A study of 100 patients with AF and CKD found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study lasted 2 years. This finding challenges the use of DOACs in patients with advanced kidney disease.
Toward multilevel therapeutic targeting of medial arterial calcification in chronic kidney disease
This review discusses targeting vascular smooth muscle cells to prevent calcification. It covers multiple targets in kidney disease patients.
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
A trial of finenorme in children with CKD and proteinuria. The study will enroll 50 patients over 18 months.
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
A trial of twice-weekly vs. thrice-weekly dialysis in veterans with kidney disease. The study will enroll 252 Veterans over 3 years.
Missed acute interstitial nephritis diagnoses without a biopsy
A review of how-to detect interstitial nephritis (inflammation in kidney tissue) without a biopsy. The authors find that using biomarkers and ultrasound may help detect this condition in patients with CKD.
Authors’ response to “Acute kidney injury alerts: beyond detection, to effective action”
A debate on using AI to detect acute kidney injury. The study uses different models for each kidney segment.
Reconsidering segment-specific Klotho regulation in renal mineral homeostasis
A debate on mineral handling in the kidney. The study uses different models for each kidney segment.
Authors’ response to “Circulating engagement or intrarenal action in signal regulatory protein α–engineered mesenchymal stem cell–derived extracellular vesicle therapy for acute kidney injury?”
A debate on whether engineered EVs work via blood cells or direct kidney action. The-s_m_p_k_t_r_e_f_c_ a: better model for kidney injury in African American patients. The study uses different cell models and