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Network pharmacology and experimental verification reveal the mechanism of hederagenin in suppressing podocyte injury in focal segmental glomerular sclerosis

Paper D Peer reviewed Preclinical

Key takeaways

Researchers tested hederagenin, a plant compound, to see if it protects kidney filter cells from damage in a scarring kidney disease (focal segmental glomerulosclerosis, or FSGS). They used computer models and lab experiments. This was done in cells, not in people, so it is very early.

Who did this work

Xiyue Tian · Rangyue Han · Xiaojiao Gu · Yuqing Li · Honglian Wang · Qiongdan Hu · Li Wang

Source

Paper · OpenAlex, CKD concept sweep (DB seed + weekly delta) · 2026-08-10
https://doi.org/10.5414/cn111952