Kidney research, 2026-08-11
The most useful news for slowing early kidney disease: SGLT2 diabetes drugs helped protect kidney function, and blood pressure drugs called ACE inhibitors and ARBs were linked to fewer new cases of kidney disease in people with diabetes. A large review also found that GLP-1 drugs, used for diabetes and weight loss, look safe and helpful even for people whose kidneys have failed. Most of the rest of today's sweep was early lab work, reference pages, and new drug and diet trials that don't have results yet.
Podocin Oligomerization links Slit Diaphragm Architecture and NPHS2 Genetics
Scientists studied how the kidney's tiny filter is built. They mapped how a protein called podocin joins together to help form the filter's mesh, and tied it to a gene (NPHS2)...
Heme-induced kallikrein-kinin system activation in hemolytic uremic syndrome
This lab study looked at a rare, serious kidney illness called hemolytic uremic syndrome, where red blood cells break apart. Researchers found that heme, a substance freed from...
Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults
Doctors described a small group of adults who make an unusual antibody (anti-factor B) that can damage the kidney's filters. They reported what these patients looked like and how...
Key Elements of Clinical Communication After Inpatient Acute Kidney Injury: Modified Delphi Study From the AKINow Recovery Workgroup
After a sudden drop in kidney function in the hospital (acute kidney injury), care can fall through the cracks once patients go home. A panel of experts agreed on the key facts...
The therapeutic approach to cardiovascular–kidney–metabolic syndrome
This review pulls together how to treat cardiovascular-kidney-metabolic syndrome, where heart, kidney, and metabolism problems feed each other. It covers screening at different...
Outcomes of Physiologic Insulin Resensitization (PIR) in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus
This is a new study, just starting, of a treatment called physiologic insulin resensitization for people who have both chronic kidney disease and type 2 diabetes. It aims to see...
A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)
This new trial tests whether empagliflozin, a diabetes and kidney drug already used in adults, helps children and teens (ages 2 to 17) with chronic kidney disease. Children are...
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
This large trial tests a new drug, BI 690517, added to empagliflozin in adults with chronic kidney disease who are at risk of getting worse. People with and without type 2 diabetes...
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
This phase 3 trial tests a drug called elecoglipron against a placebo (a dummy treatment) in adults who have type 2 diabetes and reduced kidney function. Everyone also takes the...
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
This 5-year trial tests orforglipron, a GLP-1 drug taken as a pill, against a placebo in adults with heart disease and/or chronic kidney disease. It measures whether the drug...
A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function
This is an early safety and dosing study of a drug called eloralintide in people with reduced kidney function, compared with people whose kidneys work normally. It measures how...
Study of the Quality of Life in School Aged-children With Posterior Urethral Valves
This study looks at quality of life in school-aged children born with blocked urine flow from the bladder (posterior urethral valves), a problem that can slowly harm the kidneys....
Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
This study tests whether short, controlled bursts of reduced blood flow to a limb, called ischemic preconditioning, affect blood pressure, heart rate, and inflammation in people at...
Retinal Changes in Chronic Kidney Disease: A Spectral-Domain Optical Coherence Tomography Study Correlated with Biochemical Parameters.
This study used eye scans to check whether changes at the back of the eye track with kidney damage in people with chronic kidney disease. Certain eye measurements lined up with...
Urinary Dickkopf-3 reflects renal and vascular damage in diabetic kidney disease: A cross-sectional study.
This study measured a protein called Dickkopf-3 in the urine of people with diabetes-related kidney disease. Higher levels lined up with more kidney and blood-vessel damage,...
The Therapeutic Application of Epigenetic Regulation by Natural Herbal Compounds in Kidney Diseases.
This review discusses natural plant compounds that may change how genes are switched on and off in kidney disease. All of the evidence it covers comes from cells and animals, not...
Metabolomics-Defined Subtypes of Prediabetes and Risk of Cardiovascular-Kidney-Metabolic Outcomes.
This study sorted people with prediabetes into subtypes based on chemical patterns in their blood, then tracked their risk of heart, kidney, and metabolic problems. Some subtypes...
The HFpEF-ABA Score, Incident Heart Failure, and Finerenone in Chronic Kidney Disease with Type 2 Diabetes.
This study tested a scoring tool that predicts heart failure in people who have both kidney disease and type 2 diabetes. It also looked at finerenone, a drug that protects the...
Podocyte dysfunction in kidney diseases: Mechanisms and therapeutic advances.
This is a review of how tiny kidney filter cells, called podocytes, break down in kidney disease. It also covers new treatments being studied to protect them. It is a summary of...
Gallstones and acute cholecystitis in CKD and dialysis: an underrecognized biliary burden in nephrology.
This article warns that gallstones and gallbladder infections are common but often missed in people with kidney disease and on dialysis. It asks kidney doctors to watch for this...
SGLT2 Inhibitor Use in Type 2 Diabetes in England: A Population-Based Cross-Sectional Study of Uptake of NICE Guidance.
This study checked how often doctors in England prescribe SGLT2 inhibitors, kidney-protective diabetes drugs, in line with national guidance. It found how widely the drugs are...
Safety and efficacy of glucagon like peptide-1 receptor agonism-based therapies in end-stage renal disease: A systematic review and meta-analysis.
This is a large review that combined many studies of GLP-1 drugs, the kind used for diabetes and weight loss, in people whose kidneys have failed. It looked at whether these drugs...
Network pharmacology and experimental verification reveal the mechanism of hederagenin in suppressing podocyte injury in focal segmental glomerular sclerosis
Researchers tested hederagenin, a plant compound, to see if it protects kidney filter cells from damage in a scarring kidney disease (focal segmental glomerulosclerosis, or FSGS)....
Factors of Progression of Chronic Kidney Disease in Hospitalized Patients at Chud-ba in Parakou in 2026
This study looked at hospital patients in Parakou, Benin, to find what makes chronic kidney disease get worse. It reports the main risk factors it found. Because it looks back at...
Treatment outcomes and safety of telitacicept in reducing proteinuria and hematuria for refractory childhood IgA vasculitis nephritis
This study reported how children with a hard-to-treat kidney inflammation did on a drug called telitacicept. It looked at whether the drug lowered protein and blood in the urine....
Dapagliflozin preserves kidney function and reduces albuminuria in children with chronic kidney disease
A study gave dapagliflozin, a diabetes pill that also protects kidneys, to children with chronic kidney disease. The children kept more of their kidney filtering power and had less...
Prevention of new-onset chronic kidney disease with renin–angiotensin system blockers in type 2 diabetes with preserved kidney function
This study looked at whether common blood pressure drugs called ACE inhibitors and ARBs help stop kidney disease from starting in people with type 2 diabetes whose kidneys still...
Clinicopathological features and outcomes of glomerular microangiopathy: a retrospective cohort study
This study looked back at records of people with glomerular microangiopathy, a kind of damage to the kidney's tiny filters. It describes what the disease looked like and how...
Idiopathic nodular glomerulopathy
This report describes idiopathic nodular glomerulopathy, a rare kind of kidney scarring with no clear cause. It sums up how the condition shows up in the kidney. The report gives...
A-to-I RNA editing in kidney tissue from patients with nephrotic syndrome
Scientists studied kidney tissue from people with nephrotic syndrome to look at RNA editing, a process that can affect inflammation. This is early lab work on tissue samples, not a...
Genetic and environmental risk factors for intracranial aneurysm and subarachnoid haemorrhage among patients with Autosomal Dominant Polycystic Kidney Disease
This study looked at people with polycystic kidney disease (ADPKD), an inherited disease that grows cysts on the kidneys. It checked which genes and lifestyle factors raise the...
The Urine Ammonium-pH Index is a Measure of Kidney Tubular Function
Researchers tested a new urine measure, the urine ammonium-pH index, to judge how well the kidney's tubes are working. In their data it predicted who would lose kidney function...
Anemia in CKD – KDIGO
This is an updated 2026 guideline on treating anemia, which means low blood counts, in people with kidney disease. It pulls together more than ten years of new evidence into advice...
Self-Management Data and Disease Progression in Chronic Kidney Disease
This study watches how well people with chronic kidney disease track their own blood pressure, blood sugar, medicines, and diet using a phone app linked to hospital records. It...
Effects of Replacing High Protein Foods in People With Chronic Kidney Disease
This diet study has people with chronic kidney disease add and remove red meat from their meals to see how it changes waste products in their blood and urine, including one called...
Association Between Dietary Magnesium Intake and All-Cause Mortality in Patients with Chronic Kidney Disease: Insights from NHANES 1999-2018.
This study used a large US health survey to see whether people with chronic kidney disease who eat more magnesium live longer. Higher magnesium from the diet was tied to a lower...
Integrated Analysis of Zinc, Copper, and Magnesium Homeostasis in Pediatric Idiopathic Nephrotic Syndrome: A Prospective Cohort Study with Serial Clinical Evaluation
This study followed children with idiopathic nephrotic syndrome, a kidney disease that leaks protein into the urine. It tracked blood levels of zinc, copper, and magnesium over...
Change of prognostic nutritional index after three months of initial hemodialysis is a predictor of long-term outcomes for patients with uremia
This study followed people starting dialysis and tracked a nutrition and immune score called the prognostic nutritional index. How the score changed over the first three months was...
Vascularization of Human iPSC-Derived Kidney Organoids Using Perfusion Culture, Pre-Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix.
Researchers grew tiny lab-made kidney tissues from human stem cells and worked on giving them a blood supply, using flow through the tissue and special scaffolds. Better blood...
A reference tissue atlas for the human kidney
Scientists built a detailed map of the cells inside the human kidney, in both healthy and diseased tissue. The map shows which cell types are there and how they interact. This is...
Xenotransplantation Literature Update: January-June 2026.
This is a roundup of research on animal-to-human transplants from the first half of 2026, mostly using pig organs. It pulls together what was published in that time. It is a...
Proteomic Identification of Pig Xenoantigens for Clinical Xenotransplantation.
Researchers hunted for the pig proteins that a human immune system would attack after a pig-organ transplant. Finding these targets could help make pig organs safer to use in...
Remission of Nephrotic Proteinuria after Liver Transplantation in a Case of Abernethy Malformation Type Ib and Membranoproliferative Glomerulonephritis
Doctors describe one patient who had a rare liver blood vessel problem and a kidney disease that leaked heavy protein into the urine. After a liver transplant, the protein loss...
High burden of kidney involvement in neuronal intranuclear inclusion disease
This study found that a rare brain and nerve disease, called neuronal intranuclear inclusion disease, often harms the kidneys too. It reports how common kidney damage was in these...
Prognostic determinants of solitary kidney: a comprehensive analysis of congenital and acquired cases
This study looked at people living with a single kidney, both those born that way and those who lost one. It examined what predicts how well they do over time. Because it looks...
Renal outcomes and compensatory hypertrophy in survivors of unilateral non-syndromic Wilms tumour: a single-centre cross-sectional study from a tertiary-care institution in India
This study followed childhood kidney cancer (Wilms tumour) survivors who had one kidney removed. It checked their long-term kidney health and whether the remaining kidney grew to...
Neuregulin 4 in correlation with flow mediated dilatation and transcranialDoppler in assessment of endothelial dysfunction in type 2 diabetic kidney disease patients
This study measured a blood marker called Neuregulin 4 in people with diabetes-related kidney disease. It checked whether the marker tracks with poor blood vessel function. It...
Implementation of KDIGO CKD Screening and Its Prognostic Implications in Community-Dwelling Adults Aged 75 Years or Older: A Population-Based Cohort Study
This large study screened adults aged 75 and older for chronic kidney disease using KDIGO guidelines. It then tracked what the screening results meant for their health over time....
Research Coordinators Lead KPMP Manuscript on Participant Experience in Kidney Biopsies
A published study asked people what it was like to have a research kidney biopsy, where a small tissue sample is taken for study. It was co-led by research coordinators and...