← brief for 2026-08-12 · Slowing decline

Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease: SOST and DDK1 inhibition in renal osteodystrophy

Paper D Peer reviewed Preclinical

Key takeaways

In animals with kidney disease, a lab-made antibody improved bone health and cut the fatty buildup in bone marrow. Kidney disease often weakens bones, so this targets a real problem. It was done in animals, not people, so it is early.

Who did this work

Worachet Promruk · Soher; id_orcid 0000-0001-5263-8557 Jayash · Chartinun Chutoe (Cancer Genetics (United States)) · Hua Zhu Ke (Anglia Ruskin University) · Xi Liu · Rachel Wade · Alexander von Kriegsheim (Edinburgh Cancer Research) · William P. Cawthorn (8354286) (Neurological Surgery) · Katherine A Staines (University of Brighton) · Larry Stephen · Colin Farquharson

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-12-01
https://doi.org/10.1038/s41413-026-00556-y