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Kidney research, 2026-08-12

No new kidney treatment findings arrived today, just background reading on how studies work

Key takeaways

Today was a quiet day for kidney research. The sweep mainly found educational commentary from a nephrology journal club explaining how clinical trials are built and judged, which is useful background but not new evidence. There were no graded results and nothing that affects treatment or daily decisions for someone living with stage 3 kidney disease. We would rather tell you it was a slow day than dress up weak material as news.

Slowing decline · 67

ISN Journal summaries on strategies to target the VEGF-A pathway and AKI in children with acute malnutrition - International Society of Nephrology

In mice, an antibody that blocks a blood-vessel signal called VEGFR1 improved kidney function and reduced damage from diabetic kidney disease. It even helped the animals live...

Page D Peer reviewed Forager · added 19 minutes ago

From single shots to strategy: How CAPTIVATE is reframing the NephTrials playbook — NephJC

This is an opinion essay about the rising burden of kidney disease and how kidney trials are designed and run. It shares views and background, not new study results. There is...

Page No results yet Not peer reviewed Forager · added 19 minutes ago

NephJC Short: When BAFF Meets APRIL: Telitacicept in IgA Nephropathy (TELIGAN trial) — NephJC

A phase 3 trial in China called TELIGAN tested telitacicept, a drug that calms the immune system, in adults with IgA nephropathy, a kidney disease driven by the immune system. This...

Page B Not peer reviewed Forager · added 19 minutes ago

Clinical Trials (ISN-ACT) - International Society of Nephrology

This is a regularly updated list of recent kidney trials from a nephrology society, not a single study. It points to many trials but gives no one result here. It is a directory...

Page No results yet Not peer reviewed Forager · added 19 minutes ago

FIND CKD: The Visual Abstract — NephJC

A large phase 3 trial called FIND-CKD tested finerenone, a pill that blocks a hormone that scars the kidneys, in people who have kidney disease but not diabetes. It was the first...

Page A Not peer reviewed Forager · added 19 minutes ago

Track: The Visual Abstract — NephJC

A trial called TRACK tested a low dose of the blood thinner rivaroxaban against a dummy pill in people with advanced kidney disease, including those on dialysis, who have high...

Page No results yet Not peer reviewed Forager · added 19 minutes ago

Long-term mortality and risk of chronic kidney disease in children following severe malaria complicated by acute kidney injury: a prospective observational study.

Researchers followed children who survived severe malaria that had harmed their kidneys. Over the long term, these children had a higher risk of death and of developing lasting...

Article C Peer reviewed PubMed, CKD severity and reversal · added 19 minutes ago

Impact of Anemia and Comorbidity Burden on Disease Progression and Outcomes in Chronic Kidney Disease.

This study looked at how a low blood count (anemia) and other illnesses affect people as their kidney disease worsens. People carrying more of these problems tended to decline...

Article C Peer reviewed PubMed, CKD severity and reversal · added 19 minutes ago

Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy.

Sotagliflozin is a drug that blocks two sugar-handling proteins. In this study it lowered sodium overload inside cells and eased heart damage caused by kidney failure. The work was...

Article D Peer reviewed PubMed, CKD severity and reversal · added 19 minutes ago

Diagnostic Value of Left Atrioventricular Coupling Index and Left Atrial Stiffness Index for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease: A Comparative Study Based on the 2025 ASE Guidelines.

This study tested two ultrasound measures of how well the heart relaxes in people with kidney disease. It checked how well these measures spot early heart stiffness, a common...

Article C Peer reviewed PubMed, CKD severity and reversal · added 19 minutes ago

Urinary heavy metal and trace element mixtures in chronic kidney disease: associations and implications for potential reverse causality.

Researchers measured heavy metals and trace elements in the urine of people with kidney disease and looked for patterns. They found links between certain metal mixtures and kidney...

Article C Peer reviewed PubMed, CKD severity and reversal · added 19 minutes ago

Gastric Outlet Obstruction from Brunner Gland Hyperplasia Mimicking Malignancy: A Case Report.

This is a case report about a stomach blockage. It is not about kidney disease. It is off-topic for this digest.

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Neferine, a major alkaloid from the traditional Chinese medicine Lian Zi Xin, alleviates renal fibrosis by targeting GSK3β and β-catenin signaling.

A natural compound called neferine, from a traditional Chinese medicine, reduced kidney scarring in lab tests. It seemed to work by blocking two signals that drive scarring. This...

Article D Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study.

Doctors followed children who had a stem cell transplant, over 20 years, to see how many later got long-term kidney disease. This kind of study can show a link between the...

Article C Peer reviewed PubMed, Reducing protein and albumin in urine · added 19 minutes ago

Global Burden of Key Components of Cardiovascular-Kidney-Metabolic Syndrome Among Women of Reproductive Age, 1990-2021.

This report estimated the global burden of cardiovascular-kidney-metabolic syndrome in women of childbearing age from 1990 to 2021. That syndrome links heart, kidney, and metabolic...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

10-Year Trends in Heart Failure Among Patients With Dialysis and Nondialysis CKD.

This study tracked heart failure over ten years in people with chronic kidney disease, both on dialysis and not. It shows how common heart failure has become in these patients over...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Fucoidan attenuates renal fibrosis by alleviating tubular ectopic lipid deposition through sirtuin 1/forkhead box protein O1/adipose triglyceride lipase-associated lipophagy.

Fucoidan is a compound from seaweed. In this lab study it reduced kidney scarring by clearing fat that builds up in the kidney's tiny tubes. The work was done in animals or cells,...

Article D Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Asymptomatic kidney changes discovered during occupational health screening: age-dependent trends from a large cohort.

Workplace health screening found early kidney changes in people who had no symptoms. In a large group, these hidden changes became more common with age. It shows that kidney damage...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Prevalence of type 1 and type 2 diabetes among chronic kidney disease patients and laboratorial differences between diabetics and non-diabetics.

This study counted how many people with chronic kidney disease also have type 1 or type 2 diabetes. It also compared lab test results between those with and without diabetes. It...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Intestinal paracellular phosphate absorption resists dietary adaptation but is upregulated in CKD.

This lab study looked at how the gut absorbs phosphate, a mineral that builds up in kidney disease. It found that one absorption path does not adjust to diet and gets stronger in...

Article D Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

The Impact of Renin-Angiotensin Aldosterone System Inhibitors in IgA Nephropathy: A Meta-Analysis of Randomized Controlled Trials.

This paper combined the results of several randomized trials of RAAS inhibitors, a type of blood pressure drug, in people with IgA nephropathy. IgA nephropathy is a kidney disease...

Article A Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Comparative Effectiveness and Cardiovascular Safety of Romosozumab versus Teriparatide in Osteoporosis Patients with CKD: Target Trial Emulation Study.

This study compared two bone-building drugs, romosozumab and teriparatide, in people who have both weak bones and chronic kidney disease. It looked back at real patient records to...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Self-Management Data and Disease Progression in Chronic Kidney Disease

This study will follow people with chronic kidney disease who log their blood pressure, blood sugar, medicine, and diet in a phone app. Researchers want to see if steady...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 2 hours ago

Association of fluid creep and maintenance fluids on major adverse kidney events in critically ill patients - An observational cohort study.

In very sick hospital patients, this study looked at whether extra IV fluids raised the risk of serious kidney problems. It found a link between more fluid and more kidney harm....

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 2 hours ago

[Risk factors for perioperative acute kidney injury following partial nephrectomy in patients with stage 3 chronic kidney disease].

This study looked at people with moderate (stage 3) kidney disease having part of a kidney removed. It searched for what raised their risk of sudden kidney injury around surgery....

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 2 hours ago

A-to-I RNA editing in kidney tissue from patients with nephrotic syndrome

This is early lab work on kidney tissue from people with nephrotic syndrome, a disease where the kidney leaks protein. Scientists studied a fine detail of how genes are edited...

Preprint D Not peer reviewed medRxiv nephrology preprints · added 2 hours ago

Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults

Some people make an antibody that attacks a part of the immune system called factor B. This study looked at adults with that antibody and described the range of kidney filter...

Paper C Peer reviewed AJKD · added 56 minutes ago

Key Elements of Clinical Communication After Inpatient Acute Kidney Injury: Modified Delphi Study From the AKINow Recovery Workgroup

A panel of experts agreed on the key facts doctors should pass along when a patient leaves the hospital after a sudden drop in kidney function (acute kidney injury, or AKI). The...

Paper No results yet Peer reviewed AJKD · added 56 minutes ago

A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

This early study measures how much of a new drug, eloralintide, gets into the blood and how fast the body clears it. It compares people with reduced kidney function to healthy...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

This large trial tests a new drug (BI 690517) together with empagliflozin, an SGLT2 kidney medicine, in adults with chronic kidney disease who are at risk of getting worse. People...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort

This early study checks the safety and handling of a new drug, AZD4248, in healthy people and in people with diabetic kidney disease. It also tests whether people can measure their...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

This trial tests whether empagliflozin, a kidney medicine already used in adults, helps children aged 2 to 17 with chronic kidney disease. Children are randomly given the drug or a...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)

This large five-year trial tests orforglipron, a once-daily GLP-1 pill, against a placebo. It asks whether the pill prevents heart attacks and strokes in people with heart disease,...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

Hepatic fibrosis severity assessed by FIB-4 index is independently associated with reduced kidney function in patients with metabolic dysfunction-associated steatotic liver disease: a nationwide multicenter study from Türkiye.

In people with fatty liver disease, those with worse liver scarring scores (measured by a test called FIB-4) tended to have lower kidney function. This was a large study across...

Article C Peer reviewed PubMed, fibrosis reversal · added 56 minutes ago

SGLT2 inhibitors in autosomal dominant polycystic kidney disease: rationale, evidence gaps, and ongoing clinical trials.

This review lays out the case for testing SGLT2 medicines in polycystic kidney disease, an inherited disease that fills the kidneys with cysts. It points out what is still unknown...

Article No results yet Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Mechanisms and management of IgA nephropathy progression to end-stage renal disease: From the "four-hit" theory to precision medicine.

This review explains how IgA nephropathy, an immune disease of the kidney filters, slowly leads to kidney failure. It walks from the older 'four-hit' idea toward newer treatments...

Article No results yet Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Combined use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for cardiovascular protection.

This review discusses using GLP-1 and SGLT2 medicines together to protect the heart in high-risk patients. Both drug types are also used to protect the kidneys. It is a review, so...

Article No results yet Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Potential nephroprotective mechanisms of orforglipron, an oral non-peptide GLP-1 receptor agonist.

This paper reviews how orforglipron, a new GLP-1 diabetes pill you take by mouth, might protect the kidneys. It walks through the possible ways the drug could help kidney tissue....

Article No results yet Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.

This study compared finerenone, a kidney and heart drug, with older water-pill-type drugs in people who have diabetic kidney disease. It looked at heart muscle trouble caused by...

Article C Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Semaglutide/Acarbose combination protects against diabetic nephropathy in rats; a novel insight into modulation of Nrf-2/HO-1& TGF-β/Smad pathways.

Researchers gave rats with diabetic kidney damage a mix of two diabetes drugs, semaglutide and acarbose. The combination seemed to protect the kidneys and calm the pathways that...

Article D Peer reviewed PubMed, the drug frontier · added 56 minutes ago

The HFpEF-ABA Score, Incident Heart Failure, and Finerenone in Chronic Kidney Disease with Type 2 Diabetes.

This work looked at a heart-failure risk score in people with kidney disease and type 2 diabetes, and where finerenone fits in. Finerenone is a drug that protects the kidneys and...

Article C Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Podocyte dysfunction in kidney diseases: Mechanisms and therapeutic advances.

This is a review of how podocytes, the filter cells in the kidney, break down in kidney disease. It covers what goes wrong and new treatment ideas being explored. It sums up other...

Article No results yet Peer reviewed PubMed, the drug frontier · added 56 minutes ago

Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease: SOST and DDK1 inhibition in renal osteodystrophy

In animals with kidney disease, a lab-made antibody improved bone health and cut the fatty buildup in bone marrow. Kidney disease often weakens bones, so this targets a real...

Paper D Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Epigenetic regulation of tubular epithelial cell dysfunction in diabetic kidney disease

This is a research review about diabetic kidney disease, a common cause of kidney damage. It looks at how chemical tags on DNA, called epigenetics, may change how the cells lining...

Paper No results yet Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

What is the best treatment for early-stage kidney disease?

This article discusses the best treatment for early-stage kidney disease. It is a discussion piece, not a new study, so there are no fresh results here. Talk with your doctor about...

Paper No results yet Not peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Chronic kidney disease–mineral and bone disorder among maintenance hemodialysis patients in Addis Ababa, Ethiopia: prevalence, guideline adherence, complications, and quality of life

This looked at people on dialysis in Addis Ababa, Ethiopia. It measured how common bone and mineral problems are, a frequent dialysis complication, and how they affect daily life....

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Comparison of Dialysate Calcium Concentrations and Arterial Stiffness in Dialysis Patients: A Network Meta-analysis

This pooled several studies of dialysis patients to compare different calcium levels in the dialysis fluid. It looked at how stiff the arteries became, which is a sign of heart...

Paper A Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Renal Outcomes of Triglyceride-Targeting Lipid-Lowering Therapies versus Statins in Patients with CKD

This compared kidney outcomes in people with kidney disease who took triglyceride-lowering drugs versus statins. Both are used to lower fats in the blood. Because it compares...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Blood pressure Time in Target Range and Clinical Outcomes in Chronic Kidney Disease

This studied people with kidney disease and how much of the time their blood pressure stayed in the target range. More time in range was linked to better health outcomes. This...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Factors of Progression of Chronic Kidney Disease in Hospitalized Patients at Chud-ba in Parakou in 2026

This studied patients at a single hospital in Parakou, Benin, to find what makes kidney disease get worse. Because it is one hospital watching existing patients, it shows links,...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in the Very Elderly with Chronic Kidney Disease: a Retrospective Cohort Study Using Real-World Data

This used real-world records to study SGLT2 blockers, a diabetes drug that also protects kidneys, in people 80 and older with kidney disease. Very old people were left out of the...

Preprint C Not peer reviewed medRxiv nephrology preprints · added 56 minutes ago

Genetic and environmental risk factors for intracranial aneurysm and subarachnoid haemorrhage among patients with Autosomal Dominant Polycystic Kidney Disease

This studied people with polycystic kidney disease, an inherited disease that fills the kidneys with cysts. It looked at what raises the risk of a brain aneurysm, a weak bulging...

Preprint C Not peer reviewed medRxiv nephrology preprints · added 56 minutes ago

The Urine Ammonium-pH Index is a Measure of Kidney Tubular Function

This tested a simple urine measure, called the ammonium-pH index, that reflects how well the kidney's tiny tubes handle acid. In this study the measure predicted who would lose...

Preprint C Not peer reviewed medRxiv nephrology preprints · added 56 minutes ago

2025 IgAN KDIGO guidelines: fresh out of press, already aging gracefully — NephJC

These are updated treatment guidelines for IgA nephropathy, a common cause of kidney damage. In this disease, the body's own immune system harms the kidney's tiny filters. For the...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Kidney Week in Houston: Day 2 — NephJC

This is a conference roundup, not a single study. It covers new trials shared at a large kidney meeting. One tested fish oil for people on dialysis. Another tested doing less...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Kidney Week in Houston: Day 3 — NephJC

This is a conference roundup, not a single study. It covers late-breaking trials from a major kidney meeting. One tested sibeprenlimab, a new drug for IgA nephropathy. Another...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Attacking the Origin of IgAN: ORIGIN3 and Atacicept — NephJC

A large Phase 3 trial tested a drug called atacicept for IgA nephropathy, a common cause of kidney damage. The drug aims to calm the immune signals that drive the disease. The...

Page A Peer reviewed Forager · added 56 minutes ago

Is TRPC6 inhibition for FSGS a trick or a treat? — NephJC

This was an early (phase 2) trial of a new drug, BI 764198, for FSGS, a disease that scars the tiny filters in the kidney and leaks protein into the urine. People were randomly...

Page B Peer reviewed Forager · added 56 minutes ago

Heir to the Throne? Obinutuzumab in the membranous nephropathy MAJESTY trial — NephJC

This trial compared two treatments for primary membranous nephropathy, a disease where the kidney's filter is damaged and leaks protein into the urine. People were randomly...

Page B Peer reviewed Forager · added 56 minutes ago

Autosomal Dominant Polycystic Kidney Disease (ADPKD) – KDIGO

Kidney doctors released new 2025 guidelines for polycystic kidney disease, an inherited illness where fluid-filled sacs called cysts grow in the kidneys and slowly damage them. It...

Page No results yet Peer reviewed Forager · added 56 minutes ago

2026 KDIGO Anemia Management Guidelines — NephJC

Kidney doctors published new 2026 guidelines for treating anemia in people with kidney disease. Anemia means having too few red blood cells, which can leave you tired and short of...

Page No results yet Peer reviewed Forager · added 56 minutes ago

Nephrotic Syndrome in Children – KDIGO

New 2025 guidelines cover nephrotic syndrome in children, a condition where the kidneys leak large amounts of protein into the urine. This can cause swelling and other problems....

Page No results yet Peer reviewed Forager · added 56 minutes ago

Making an IMPACT on BP: Why pills alone won't win the war — NephJC

This is a journal club discussion about high blood pressure and the kidneys. High blood pressure affects over 1.3 billion adults and harms both the kidneys and the heart. The...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Anemia in CKD – KDIGO

This is a new 2026 guideline on treating anemia, a low red blood cell count, in people with kidney disease. It updates the older 2012 version and gathers a decade of new evidence...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Finerenone across the proteinuric CKD spectrum — NephJC

This is a journal club discussing finerenone, a drug that lowers protein in the urine and helps protect the kidneys. Two 2026 papers extended the evidence beyond diabetes,...

Page B Not peer reviewed Forager · added 56 minutes ago

NephJC Short: 24-Month Iptacopan eGFR Data in IgA Nephropathy — NephJC

This is a journal club covering 24-month results for iptacopan, a drug for IgA nephropathy, a common kidney disease. It comes from APPLAUSE-IgAN, a large late-stage randomized...

Page A Not peer reviewed Forager · added 56 minutes ago

https://www.era-online.org/publications/causal-assessment-of-ckd-mbd-biomarker-alterations-on-ckd-progression-through-a-g-formula-analysis-in-the-equal-study/

This published study looked at whether changes in bone and mineral blood markers, such as phosphate, are tied to faster kidney decline in people with advanced kidney disease. Using...

Page C Peer reviewed Forager · added 56 minutes ago
Nutrition & lifestyle · 14

Rational Design and Optimization of MCh-AMP1: A Stable α-Helical Antifungal Peptide with Enhanced Activity Against Candida albicans.

This is a lab study designing an antifungal molecule to fight a yeast infection. It has nothing to do with kidney disease. It is off-topic for this digest.

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Five days of heat acclimation improves cardiovascular and thermoregulatory responses without altering renal stress biomarkers in endurance athletes.

This study looked at heat training in healthy endurance athletes and found no change in kidney stress markers. It is about fit athletes, not people with kidney disease. It is...

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Exercise-induced rhabdomyolysis following a swimming session complicated by acute kidney injury: a case report.

This is a single case report of one person whose kidneys were briefly harmed after hard exercise, a swimming session. A single case cannot tell us how common this is or prove...

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Alisols A-C and their acetate derivatives: a review of natural occurrence, pharmacology, semisynthesis, pharmacokinetics, and metabolism.

This is a chemistry and pharmacology review of some natural plant compounds. It is not focused on kidney disease and reports no new results in people. It is off-topic for this...

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

The flavonoid isoliquiritigenin promotes lifespan extension of Caenorhabditis elegans through the transcription factor DAF-16 and aquaporin-2.

This was a study of a plant compound and lifespan in tiny worms. It is not about kidney disease in people. There is nothing here that helps a kidney patient.

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Real-world effectiveness and safety of difelikefalin for chronic kidney disease-associated pruritus: a systematic review.

This review gathered real-world reports on difelikefalin, a drug for the severe itch that kidney disease can cause. It looked at how well the drug worked and how safe it was...

Article C Peer reviewed PubMed, Lifestyle and CKD · added 19 minutes ago

Bifid triple viable tablets are associated with renal biochemical improvement and qualitative gastrointestinal changes in 5/6-nephrectomized rats: An exploratory microbiome-metabolome study.

This study gave a probiotic tablet to rats that had most of their kidney removed, a common way to model kidney disease. The rats showed better kidney blood tests and changes in...

Article D Peer reviewed PubMed, Nutritional supplements and CKD · added 19 minutes ago

Global and national burden of chronic kidney disease attributable to fine particles: An updated exposure-response meta-analysis.

This review pooled many studies on tiny air pollution particles, called fine particulate matter, and chronic kidney disease. It estimated how much kidney disease worldwide may be...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases.

This study tracked lifestyle and metabolic health against albuminuria, which means protein leaking into the urine and is an early sign of kidney damage. It links healthier habits...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Effects of Replacing High Protein Foods in People With Chronic Kidney Disease

This crossover trial looks at how eating red meat changes gut-related toxins in the blood and urine of people with chronic kidney disease. One such toxin is TMAO, which is tied to...

Trial No results yet Not peer reviewed ClinicalTrials.gov, CKD recruiting · added 56 minutes ago

Long-Term Heatwave Exposure and Kidney Function Decline in Korean Adults: A Nationwide Cohort Study

This large study in South Korea checked whether long spells of very hot weather harm the kidneys. Adults with more heatwave exposure over time had a faster drop in their kidney...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

The Dietary Approaches to Stop Hypertension (DASH) diet score and its association with the Risk of Kidney Function Decline and Mortality among Veterans in the Million Veteran Program

A very large study followed 251,921 U.S. veterans and scored how closely they followed the DASH eating plan, which is rich in fruit and vegetables and low in salt. People who...

Preprint C Not peer reviewed medRxiv nephrology preprints · added 56 minutes ago

Change of prognostic nutritional index after three months of initial hemodialysis is a predictor of long-term outcomes for patients with uremia

This followed people starting dialysis and tracked a nutrition and immune score in their blood. People whose score dropped over the first three months did worse over the long term....

Preprint C Not peer reviewed medRxiv nephrology preprints · added 56 minutes ago

The Protein Pendulum in CKD: supplement or restrict? — NephJC

This is a discussion, not a new study. Doctors have long told people with kidney disease to eat less protein. The worry is that too much protein makes the kidneys work too hard....

Page No results yet Not peer reviewed Forager · added 56 minutes ago
Mind-body · 1

Prediction of depression risk in chronic kidney disease using PSO-optimized random forest: a web-based application based on CHARLS data

Many people with kidney disease also struggle with depression. This study built a computer tool to predict who is most at risk, using survey data from older adults in China. The...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 2 hours ago
Regeneration & devices · 6

Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.

This is a lab study about how a virus copies itself inside cells. It is not about kidney disease. It is off-topic for this digest.

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

A nanoluciferase-expressing attenuated CHIKV vaccine strain enables rapid and visual drug screening in vitro and in vivo.

This is a lab study about a virus vaccine strain used for drug screening. It is not about kidney disease. It is off-topic for this digest.

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Inhibition of the Notch signaling pathway promotes AQP2 plasma membrane accumulation in renal epithelial cells by depolymerizing actin and reducing endocytosis

This is early lab work in kidney cells, not people. Scientists blocked a cell signal called Notch and watched a water channel named AQP2 move to the cell surface. This channel...

Preprint D Not peer reviewed bioRxiv cell biology (kidney-filtered downstream) · added 2 hours ago

Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles as Antifibrotic Nanotherapeutics for Chronic Kidney Disease.

Researchers built tiny particles released by stem cells and used them to fight kidney scarring. Early tests suggest the particles can lower scarring in chronic kidney disease. This...

Article D Peer reviewed PubMed, fibrosis reversal · added 56 minutes ago

Vascularization of Human iPSC-Derived Kidney Organoids Using Perfusion Culture, Pre-Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix.

Scientists grew tiny lab-made kidneys, called organoids, from stem cells. They added blood-vessel networks using flow culture and special scaffolds to keep the tissue alive and...

Article D Peer reviewed PubMed, organoids & devices · added 56 minutes ago

Is REACT (Renal Autologous Cell Therapy) the “fifth pillar” in diabetic kidney disease? — NephJC

REACT is an experimental therapy for diabetic kidney disease. Doctors take a small sample of a person's own kidney cells, grow more, and inject them back to try to repair the...

Page No results yet Not peer reviewed Forager · added 56 minutes ago
Transplant & xeno · 10

Beyond rewarming time: graft thermometry and cooling technologies in robot-assisted kidney transplantation-a scoping review.

This is a review of ways to keep a donor kidney cool during robot-assisted transplant surgery. Keeping the kidney cold while it is placed may protect it, and the review surveys...

Article No results yet Peer reviewed PubMed, Climate, heat and the kidney · added 19 minutes ago

Pre-Transplant Left Atrial Volume Index and One-Year Morbidity After Kidney Transplantation.

This study measured the size of the heart's left upper chamber before a kidney transplant. It checked whether a larger chamber linked to more health problems in the first year...

Article C Peer reviewed PubMed, Lifestyle and CKD · added 19 minutes ago

Machine Perfusion and Mitigating Risk Factors for Delayed Graft Function in Pediatric Kidney Transplant Recipients.

This work looked at machine perfusion, a way of keeping a donor kidney supplied with fluid before transplant, in children. The goal was to lower the risk of the new kidney being...

Article C Peer reviewed PubMed, CKD progression and prevention · added 19 minutes ago

Xenotransplantation Literature Update: January-June 2026.

This article summarizes the last six months of research on animal-to-human transplants (xenotransplantation). It is a roundup of the field, so it reports no new results of its own.

Article No results yet Peer reviewed PubMed, xeno · added 56 minutes ago

Obesity management for kidney TRANSPLANTation: protocol for the vanguard phase of an innovative randomised controlled trial, embedded in routine care (OK-TRANSPLANT 2).

This is the plan for a new trial testing weight-loss and obesity care for people getting a kidney transplant. It is built into normal care to see if it works in the real world. The...

Article No results yet Not peer reviewed PubMed, the drug frontier · added 56 minutes ago

[Incidence and associated factors of anemia within six months after kidney transplantation in pediatric recipients].

This study followed children after a kidney transplant to see how many got anemia, meaning too few red blood cells. Anemia showed up often in the first six months, and the study...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Growing Evidence for Subnormothermia for Graft Recovery in Donation After Circulatory Death Kidney Transplantation

This discusses keeping donor kidneys slightly cool, below body temperature, before a transplant. The goal is to help kidneys from donors who have died recover better. The authors...

Paper No results yet Not peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 56 minutes ago

Chimerism and Immune Tolerance: Can We Says Goodbye to Immunosuppression? — NephJC

This is a discussion piece, not a new study. It explains a way to help the body accept a new kidney without lifelong anti-rejection drugs. Doctors give the patient some of the...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Clinical Trials for Pig-to-Human Kidney Transplantation Are Here

US regulators approved the first American clinical trials of pig-to-human kidney transplants. This is called xenotransplantation, and the aim is to ease the shortage of human donor...

Page No results yet Not peer reviewed Forager · added 56 minutes ago

Woman Undergoes First in World Transvaginal Robotic-Assisted Dual Kidney Transplant

A 76-year-old woman became the first person to receive two donor kidneys through keyhole, robot-assisted surgery done through the vagina instead of a large abdominal cut. She...

Page No results yet Not peer reviewed Forager · added 56 minutes ago
People & money · 7

Terms and Conditions | ERA

This is a website terms and conditions page from a kidney society. It has no research content. It is off-topic for this digest.

Page No results yet Not peer reviewed Forager · added 19 minutes ago

ISN Insight bi-weekly newsletter - Subscribe to ISN newsletter

This is a newsletter and conference sign-up notice from a kidney society. It reports no study results. It is an announcement, not research.

Page No results yet Not peer reviewed Forager · added 19 minutes ago

Trending Topics - Kidney International® and Kidney International Reports®

This is a journal promotion page listing popular articles. It reports no single study or result. It is a navigation page, not research.

Page No results yet Not peer reviewed Forager · added 19 minutes ago

Examining variations in adherence to guideline-recommended post-acute kidney injury care in primary care in England: a population-based cohort study

This large study in England checked how often family doctors gave the recommended follow-up care after a sudden kidney injury. It found care often fell short of guidelines. It...

Paper C Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 2 hours ago

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

This project built a training to help kidney doctors talk about treatment choices in advanced kidney disease. It studies real conversations closely to teach clearer talks about...

Paper No results yet Peer reviewed OpenAlex, Kidney disease concept sweep (verified C2778653478) · added 2 hours ago

United Therapeutics Corporation Acquires Thymmune Therapeutics

United Therapeutics bought Thymmune, a small company that makes lab-grown thymus cells. The thymus is the organ that helps train the immune system. The goal is to help the body...

Page No results yet Not peer reviewed Forager · added 2 hours ago

Study Sheds Light on Transportation Barriers in Dialysis and Why Patient Voices Matter

Many people on in-center dialysis do not have a reliable way to get to their treatments. This article describes a study, called EnROUTE, that looked at 115,982 adults on dialysis...

Page No results yet Not peer reviewed Forager · added 56 minutes ago