← brief for 2026-08-12 · Slowing decline

Mechanisms and management of IgA nephropathy progression to end-stage renal disease: From the "four-hit" theory to precision medicine.

Key takeaways

This review explains how IgA nephropathy, an immune disease of the kidney filters, slowly leads to kidney failure. It walks from the older 'four-hit' idea toward newer treatments matched to each patient. It is a review, so it reports no new data.

Who did this work

Zhou T · Liu S · Zhang H · Ji Y · Lv W

Source

Article · PubMed, the drug frontier · 2026 Aug 12
https://pubmed.ncbi.nlm.nih.gov/42584021/