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Kidney outcomes and safety of sodium-glucose cotransporter-2 inhibitor therapy in autosomal dominant polycystic kidney disease: systematic review and meta-analysis.

Key takeaways

Researchers combined the results of many past studies to see if SGLT2 inhibitors help people with polycystic kidney disease. That is an inherited disease where fluid-filled sacs called cysts grow on the kidneys. These drugs are already used to protect the kidneys in other diseases. This review checked both how well they worked and whether they were safe. Pooling many studies like this is the strongest kind of evidence. The detailed numbers were not included in what we received, so we cannot yet say how large the benefit was.

Who did this work

Kanbay M · Mizrak B · Cig E · Karakaya E · Copur S · Covic A · Ortiz A · Mallamaci F · Zoccali C

Source

Article · PubMed, the drug frontier · 2026 Aug 12
https://pubmed.ncbi.nlm.nih.gov/42586506/