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Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.

Article D Peer reviewed Preclinical

Key takeaways

This study used-cell culture models to show how the virus uses the ER-phagy pathway to replicate. It targets the receptor-re-binding site of the protein.

Who did this work

Mao J · Yu J · Zeng P · Yang X · Shi Y · Qu Y · Zhou J · Wang D · Song J · Wang Y · Liu J · Hou L

Source

Article · PubMed, Climate, heat and the kidney · 2026 Aug 11
https://pubmed.ncbi.nlm.nih.gov/42576627/