← brief for 2026-08-13 · Nutrition & lifestyle
The flavonoid isoliquiritigenin promotes lifespan extension of Caenorhabditis elegans through the transcription factor DAF-16 and aquaporin-2.
Key takeaways
This study used C. elegans worms to show that the flavonoid ISL can extend lifespan by targeting longevity genes. Results in humans are unknown.
Who did this work
Zhao X · Ren L · Gu D · Yao Y · Wang S · Gao J · Qi Y
Source
Article · PubMed, Climate, heat and the kidney · 2026 Aug 7
https://pubmed.ncbi.nlm.nih.gov/42585373/