← brief for 2026-08-13 · Slowing decline

Targeted inhibition of gut microbial trimethylamine-N oxide production fosters regression of chronic kidney disease phenotypes

Paper D Not peer reviewed Preclinical

Key takeaways

This study in-human kidney cells found that targeting gut bacteria could slow kidney decline. It has not been tested in humans yet.

Who did this work

Joseph A. DiDonato (Cleveland Clinic) · Taylor L. Weeks (Cleveland Clinic) · Nilaksh Gupta (Cleveland Clinic) · Deepthi P. Mallela (Cleveland Clinic) · Jennifer A. Buffa (Cleveland Clinic) · Zeneng Wang (Cleveland Clinic) · Xinmin S. Li (Cleveland Clinic) · James T. Anderson (Cleveland Clinic) · Xiaoming Fu (Cleveland Clinic) · Naseer Sangwan (Cleveland Clinic) · Ina Nemet (Cleveland Clinic) · Scott J. Cameron (Cleveland Clinic)

Source

Paper · OpenAlex, CKD works · 2026-08-11
https://doi.org/10.5281/zenodo.17956371