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Succinate promotes renal inflammation and fibrosis by activating the NLRP3 inflammasome in macrophages via GPR91 signaling

Key takeaways

This study used mice to show that succinate promotes kidney inflammation and scarring. Results not yet proven in humans.

Who did this work

Yan Zhang (Central South University) · Jiawei Cheng (Central South University) · Xiaohua Liao (Central South University) · Xin He (Central South University) · Sijue Zou (Central South University) · Jianhua Zeng (Central South University) · Yiwei Xiong (Central South University) · Qiongjing Yuan (Central South University) · Yanyun Xie (Central South University) · Ling Huang (Central South University) · Shao Liu (Central South University) · Qianbin Li (Central South University)

Source

Paper · OpenAlex, CKD works · 2026-08-12
https://doi.org/10.1186/s10020-026-01585-3