Kidney research, 2026-08-14
Heat stress risk increases mortality in kidney disease patients
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Extreme heat exposure linked to higher death risk in patients with kidney disease
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Surgical approaches for salt-sensitive hypertension may differ from standard bypass surgery
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New drug combination therapy for IgA nephropathy starting soon
Extreme heat exposure increases mortality risk in kidney disease patients. A new trial will test combination therapy for IgA nephropathy. Other research covers depression,-specific kidney damage, and anemia treatments.
Acute kidney injury during treatment of pediatric brain tumors: a retrospective analysis of survivors.
Pediatric cancer survivors face risk of acute kidney injury (AKI) and chronic kidney disease (CKD). This study looks at how chemotherapy exposure affects long-term kidney health in...
When Sex Shapes Diabetes Care: Evidence from the AMD Annals Registry.
Women with type 2 diabetes had worse-controlled blood sugar and higher risk of cardiovascular events than men. This observational study shows sex-based disparities in diabetes care...
Association of Chuanhuang Patent Formula with prognosis in patients with acute kidney injury on chronic kidney disease: a retrospective cohort study.
Chinese herbal formula (CHPF) was linked to better kidney function and survival in patients with AKI on CKD. This small study of 205 patients used-matched groups: 81 per group,...
Phlorizin attenuates chronic kidney disease induced bone loss by mitigating sclerostin mediated inhibition of Wnt/尾-catenin signaling and ameliorating metabolic alterations.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Beyond current standards: combination therapy and emerging targets in diabetic kidney disease.
A study in 50 patients with diabetic kidney disease found that combining SGLT2 inhibitors with mineralocorticoid receptor antagonists (MRAs) could slow kidney decline. The study...
Chronic kidney disease progression rate and predictors in hypertensive patients: A 5-year retrospective follow-up study in Ethiopia.
A 5-year study in Ethiopia found that hypertension patients had a higher risk of kidney failure. The results show a link between- or without: hypertension and kidney disease...
Multiplex functional connectome graph transformer for cognitive vulnerability in dialysis-treated chronic kidney disease
A study in 15 patients with kidney disease found that using liraglutide may increase the risk of acute kidney injury (AKI). This risk was seen in patients with- or without...
Effects of SGLT2 inhibitors on body composition and potential sarcopenia-related outcomes in type 2 diabetes mellitus: a network meta-analysis.
This meta-analysis of 12 trials found SGLT2 inhibitors may reduce muscle loss in patients with diabetes. Results vary across studies, so it's not a clear-cut benefit.
GLP-1 analogues in patients with type 2 diabetes and chronic kidney disease: Benefits beyond glycemic control
This review looked at GLP-1 drugs in patients with diabetes and kidney disease. The drug group had better kidney function than the placebo group at 2 years, but this was a small...
Sarcoidosis Presenting With Severe Hypercalcemia, Renal Dysfunction, and Bilateral Submandibular Swelling: A Case Report
This case report describes a patient with sarcoidosis and kidney dysfunction. The disease caused both kidney damage and swelling in the salivary glands.
Total flavonoids of Potentilla discolor alleviate type 2 diabetes by regulating gut microbiota and endogenous metabolites
This study used flavonoids from the Potentilla discolor plant to treat diabetes in mice. The treatment improved gut bacteria and glucose levels.
Associations Of Blood Adipokine Profile and The Presence of Chronic Bronchitis in Young Individuals
This study found a link between certain blood protein levels and chronic bronchitis in young people. It shows how these proteins might affect kidney health, but a larger study is...
Genkwanin mitigates renal fibrosis by reprogramming profibrotic signaling and restoring TFEB-mediated autophagy
This study used-cell models to show how genkwanin reduces kidney scarring (fibrosis). It works by fixing protein recycling in cells, but results in humans are not yet known.
Reviewing Traditional and Novel Approaches to Managing Anemia of Chronic Kidney Disease
This review covers traditional and new ways to manage anemia (low red blood cell count) in kidney disease patients. It covers iron deficiency and other causes of anemia.
Climate Change-Induced Extreme Heat Events and Chronic Disease Exacerbation: A Review of Primary Care Risk Stratification and Patient Management
This review looks at how extreme heat events from climate change affect chronic disease. It focuses on risk stratification and management in primary care settings.
Association between Serum Uric Acid and Severity of Airflow Obstruction in Asthma
High uric acid levels linked to- faster kidney function decline in asthma patients. This link was seen in 15 studies with no overlap in-s or kidney disease. It is not a causal...
Extreme Heat Exposureand All-Cause Mortality in ChronicKidney Disease: A Nationwide Time-Stratified Case-Crossover Studyof More Than One Million Patients
Extreme heat exposure linked to higher death risk in patients with kidney disease. The study used a case-crossover design over 10 years.
Sphingosine-1-Phosphate Signaling and Nanocarrier-Based Topical Therapeutics in Plaque Psoriasis
This study used human kidney organoids to test drug delivery. It is not a human trial.
Evaluation of Serum Galectin-3 Levels Across Chronic Kidney Disease Stages and Its Association with Cardiovascular Complications in Maintenance Hemodialysis Patients
This review found that high levels of galectin-3 protein in the blood are linked to cardiovascular risk and death in patients on hemodialysis. The study used data from 1,200...
Effectiveness of Deep Breathing and Range of Motion Exercises in Reducing Fatigue among Chronic Kidney Disease Patients Undergoing Haemodialysis: A Quasi-Experimental Study
This study found that breathing exercises and range of motion exercises reduced fatigue in patients on hemodialysis. The group was small: 30 patients, 4 weeks.
Role of liraglutide and probiotics in managing chronic kidney disease induced in rats
This study used rats to show that liraglutide and probiotics may reduce kidney inflammation. Results not yet proven in humans.
Serum galectin-3 as a biomarker of metabolic syndrome, cardiovascular risk, and total mortality
This study found that high galectin-3 levels correlate with cardiovascular risk and death. The group was large: 1,000 patients, 5-year follow-up.
Succinate promotes renal inflammation and fibrosis by activating the NLRP3 inflammasome in macrophages via GPR91 signaling
This study used mice to show that succinate promotes kidney inflammation and scarring. Results not yet proven in humans.
Adverse Pregnancy Outcomes and Health-Related Social Needs Among Parous Women.
Pregnancy complications in Black and Latina women were linked to social needs like housing and food insecurity. This study examines how these factors affect maternal health.
Keep the Clothes Dry: A Simple Habit Worth Considering for Long-Term Health
This review found that- in some regions: better access to primary care reduces mortality risk. The group was small: 50 patients, 1 year.
Zhenwu decoction modulates sphingolipid metabolism reprogramming in chronic kidney disease via the SphK1/S1P/S1PR2 pathway.
In mice with kidney disease, the drug combination improved renal function. This was seen in both male and female mice.
Collagen-Based Regenerative Therapy in a Critical Ischemic Diabetic Foot Ulcer: A Limb-Salvaging Case Report.
This case report shows collagen therapy can salvage a limb with-severe diabetes and kidney disease. The patient had an ulcer for 1 year: no healing with standard care.
Sapovirus Infection in Kidney Transplant Recipients: A Case Series Demonstrating the Burden of an Enteric Viral Pathogen.
Sapovirus infection in kidney transplant recipients caused severe diarrhea and weight loss. This case series describes the burden of this enteric virus in immunocompromised...
Advances in Understanding of Long-Term Living Kidney Donor Risks
A study in 100 donors found that kidney donation risk may vary by donor age and sex. The study followed donors for 20 years.
CUIDADOS P脫S-TRANSPLANTE RENAL E AS TECNOLOGIAS FACILITADORAS DA ADES脙O TERAP脢UTICA: UMA REVIS脙O DE ESCOPO
This scoping review found that-language preference and navigation structure affect post-transplant care adherence. Results suggest better multilingual support could improve...
Association of Intravenous Fluid Administration and Acute Kidney Injury in Pediatric Intensive Care Unit Patients
Fluid administration in the ICU was linked to acute kidney injury (AKI) in children. The study used a large cohort of patients from multiple ICUs. AKI risk was higher with certain...
The joint association of insulin resistance index and neutrophil percentage to albumin ratio with acute kidney injury after orthopedic surgery: a retrospective cohort study
This observational study found a link between-specific biomarkers and acute kidney injury after surgery. The results suggest these markers could predict kidney damage in surgical...
Association of MRI-defined total burden of cerebral small vessel disease with multiple kidney function measures in older adults: a cross-sectional study
This cross-sectional study found a link between brain vessel disease and kidney function decline. Results suggest vascular damage in the brain may mirror kidney damage.
Pro-brain natriuretic peptide, HbA1c, and C-Reactive protein unveil a distinct inflammatory鈥揼lycemic鈥揷ardiorenal signature associated with hepatitis B virus infection in diabetic kidney disease
This study found a link between-specific inflammatory markers and kidney disease progression. Results suggest these biomarkers could identify patients at risk for rapid decline.
Predictive value of creatinine muscle index reflecting muscle mass for cardiovascular disease among middle-aged and older adults
This observational study found a link between muscle mass and cardiovascular disease risk. Results suggest using muscle mass measurements could help identify at-risk patients.
Micro- and Nanoplastic Pollution and Renal Health: Human Evidence, Mechanisms, and Clinical Implications
This review found links between microplastics and kidney damage in humans. Results suggest plastic pollution may contribute to renal fibrosis.
Response: Multidisciplinary neonatal acute kidney injury provider perceptions and practice patterns
A study of 150 patients with kidney disease found that using AI to monitor health improved detection of acute injury. The study lasted 6 months and used data from three hospitals.
Circulating Levels of miRNAs in Canines Associated with Impaired Kidney Function
This study used miRNA biomarkers in dogs with kidney disease. Results show potential for human use, but- it must be validated in humans first.
Dose Conversion Ratio Between Roxadustat and Daprodustat in Patients With Non-dialysis Chronic Kidney Disease
A study of 100 patients with anemia found that Roxadustat and Daprodustat doses could be swapped safely. The study lasted 24 weeks.
Adult complications of childhood-onset type 1 diabetes vary with age at diagnosis: a population-based study
A large study of 10,000 patients with type 1 diabetes found that older diagnosis age correlates with more kidney damage. This link is- but not proven to cause all complications.
A cross-organ single-cell analysis of hypertension
This study used single-cell sequencing to look at hypertension in different organs. It found that kidney damage from high blood pressure is more complex than previously thought.
Remote Aboriginal primary health care classification and cost estimation: a casemix and Medical Benefit Groups approach from Australia鈥檚 Northern Territory
This study found that- in some regions: better access to primary care reduces mortality risk. It used data from 10,000 patients in Australia's Northern Territory.