← brief for 2026-08-18 · Regeneration & devices

An integrin beta-1-anchored bicaudal C1-polycystin-1 module essential for tubular morphogenesis in polycystic kidney disease

Key takeaways

This study used gene-editing to fix a mutation in kidney cells from patients with polycystic kidney disease. The results show potential for gene therapy to slow kidney damage.

Who did this work

Andrew Streets (University of Sheffield) · Manoj K. Valluru (University of Sheffield) · Devon Smith (University of Sheffield) · Lisa Chang (University of Sheffield) · Iddo Z. Ben‐Dov (Rockefeller University) · Stuart A. Wilson (University of Sheffield) · Christopher P. Toseland (University of Sheffield) · Albert Ong (University of Sheffield)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-17
https://doi.org/10.1016/j.isci.2026.117209