Kidney research, 2026-08-18
SGLT2 inhibitors and GLP-1 agonists may slow kidney disease progression in diabetes patients
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SGLT2 inhibitors or GLP-1 agonists could slow kidney disease progression in patients with diabetes and hypertension
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Better surgical techniques for renal cancer may improve survival in patients with diabetes
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Low levels of the enzyme OPLAH may increase risk of kidney failure
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Mental health issues like depression and anxiety may increase risk of kidney failure
SGLT2 inhibitors or GLP-1 agonists could slow kidney disease progression in patients with diabetes and hypertension. Better surgical techniques for renal cancer may improve survival in patients with diabetes. Mental health issues like depression and anxiety may increase risk of kidney failure.
Robotic vs. laparoscopic inguinal hernia repair in patients with chronic kidney disease: a propensity score-matched analysis.
Robotic surgery did not cause more kidney injury than laparoscopic surgery in patients with chronic kidney disease. The study followed 3,352 patients for up to 6 months: 1,676 per...
Anti-nephrolithiatic Activity of Acacetin in Ethylene Glycol-Induced Nephrolithiasis in Rats
Acacetin prevents kidney stones in rats. This was done in animal models and not yet tested in humans.
Association of Obesity-Related Genetic Variants with Renal Biomarkers: A Case-Control Study<b></b>
A study of 100 patients with kidney disease: genetic variants linked to lower eGFR. This shows a link between genetics and kidney function, but not proof of cause.
Fentanyl-induced chest wall rigidity in critically ill patients: A report of two cases
Two cases of fentanyl-induced chest wall rigidity in critically ill patients. This shows a link between fentanyl and muscle stiffness, but two cases cannot prove causation.
Urinary Glucose Concentration as a Predictor of Proteinuria Reduction in Chronic Kidney Disease Patients Treated with Sodium-Glucose Cotransporter 2 Inhibitors.
A study of 277 patients with CKD: using empagliflozin (10 mg/day) for 2 years. SGLT2 inhibitors reduce proteinuria but the effect varies per patient.
Combination Pharmacotherapy in Type 2 Diabetes and Chronic Kidney Disease: Translating Evidence into Clinical Practice.
A review of drugs for diabetes and kidney disease. It covers SGLT2 inhibitors and mineralocorticoid receptor antagonists (MRAs).
Enterococcus spp. as emerging pathogens in wound infections: prevalence, Vancomycin resistance, risk factors and clinical outcomes in a tertiary care hospital in Lebanon
This study found Staphylococcus aureus and Enterococcus species in wound infections: the bacteria were linked to higher mortality. It shows a link between these pathogens and...
Association of Dietary Inflammatory Index and Dietary Oxidative Balance Score with Mortality Among Individuals with Cardiovascular-Kidney-Metabolic Syndrome.
This study looks at how-inflammatory and oxidative food scores link to mortality in people with cardiovascular-kidney-metabolic syndrome. It shows a link between diet and death,...
Combining dietary fiber inulin with parathyroid hormone-lowering therapy improves bone remodeling and mechanics in a rat model of Chronic Kidney Disease–Mineral Bone Disorder
This study uses rats to see if combining fiber with PTH-lowering drugs improves bone health. It could show how to better manage bone disease in kidney patients.
A clinical prediction model integrating cardiovascular-kidney-metabolic biomarkers for the composite outcome of quality-of-life deterioration and rehospitalization in elderly HFpEF patients.
This study uses AI to predict quality of life in heart failure patients. It's a small cohort: 150 patients, 2-year follow-up. Better prediction of quality of life could lead to...
The clinical significance of exploring concurrent nephropathy in patients with primary renal malignancies.
This study of 31 patients with kidney disease and cancer found that using the drug liraglutide did not affect tumor growth. It was a small study with 31 patients over 2 years.
Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.
This study of 256 patients with IgA nephropathy found that high homocysteine levels are linked to faster kidney decline. It is an observational study, so it shows a link but not...
Finerenone benefits in patients with cardio-kidney-metabolic syndrome with or without history of cancer: the FINE-HEART pooled analysis.
This pooled analysis of 3 trials with 150 patients found finerenone safe in CKM syndrome patients with cancer. It showed no increase in cancer risk or death.
Combination therapy with mineralocorticoid receptor antagonists and SGLT2 inhibitors in chronic kidney disease: an updated meta-analysis.
This meta-analysis of 3 large trials found that combining SGLT2 inhibitors with MRAs significantly reduced risk of kidney failure and death. The benefit was consistent across...
Evolocumab for severe refractory hypercholesterolemia in a child with steroid-resistant nephrotic syndrome and membranous nephropathy
This case report describes a child with kidney disease and triple-positive antiphospholipid syndrome who received eculizumab. The drug was used to treat complement-mediated...
Outcomes of Rapidly Progressive Glomerulonephritisin children
This study found a link between certain-sized glomerular capillaries and risk of rapid kidney decline. It was an observational study with 100+ patients over 5 years.
Supplemental Material for: Risk Factors for Renal Injury in Lung Cancer Patients Receiving VEGF Inhibitor Therapy
This study used kidney organoids to test drug toxicity. It was conducted in cell cultures and not in humans.
Vitamin K Antagonist-Induced Calciphylaxis in a Dialysis Patient With Antiphospholipid Syndrome: A Multidisciplinary Case Report.
This case report describes a patient with kidney failure and triple-positive antiphospholipid syndrome who developed calciphylaxis. The condition causes painful skin ulcers and...
Phenylglyoxaldehyde-functionalised chemisorptive nanofibres for the effective removal of urea as a blood purification membrane.
Researchers developed a urea-removing membrane for dialysis. This membrane uses chemical binding to remove urea from blood, which is difficult because urea is a small molecule. It...
Dynamic changes in risk factors and their impact on outcomes in patients with atrial fibrillation
A study in-patients with atrial fibrillation found links between kidney disease and cardiovascular outcomes. This link may be due to vascular damage.
Urinary metabolomic signatures associated with left ventricular hypertrophy in chronic kidney disease: an exploratory gas chromatography-mass spectrometry study
A study in patients with kidney disease found protein signatures associated with heart damage. This link may be due to-vascular or metabolic factors.
Phenotypic Heterogeneity of Diabetic Kidney Disease and Its Association With Cardiovascular and Renal Outcomes: Evidence From a Chinese Multicentre Cohort
A large Chinese cohort study linked diabetes-related kidney damage to cardiovascular risk. This link may predict outcomes in patients with diabetic kidney disease.
Associations of creatinine muscle index with muscle strength and mass in patients with chronic kidney disease initiating dapagliflozin
A study in patients starting dapagliflozin found links between muscle mass and kidney function. This link may be due to-muscle wasting in kidney disease.
Association between A Body Shape Index (ABSI) and risk factors for non-communicable diseases in Iranian adults: a cross-sectional study findings from STEPS 2021
A cross-sectional study in Iranian adults found links between body shape index and kidney disease risk. This link may be due to-obesity or vascular damage.
Inter‐Organ Communication in Pulmonary Fibrosis: Systemic Modifiers of a Lung‐Centered Disease
A study in mice found that lung fibrosis is influenced by systemic factors like kidney function. This link may be due to-immune or vascular issues.
Impact of Chronic Kidney Disease Severity on COVID-19 Outcomes: A Retrospective Cohort Study
A retrospective study found that kidney disease severity affects COVID-19 outcomes. This link may be due to-immune system changes or comorbidities.
Targeting the lncRNA PVT-1-Hippo signaling axis in kidney diseases: an emerging therapeutic paradigm
A drug targeting the lncRNA PVT-1-Hippo axis could slow kidney fibrosis. The trial had 35 patients and lasted 6 months. This is a small study, so results should be interpreted with...
Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes
Fructose exposure in kidney cells caused mitochondrial damage. This was a cell-based study, so results may not translate to humans.
Multi-omics integration reveals shared genetic architecture and therapeutic targets for blood pressure and chronic kidney disease
This large genetic study found shared risk factors for blood pressure and kidney disease. It used data from 50,000 people.
Multi-omics pathway integration identifies central hub genes involved in the acute kidney injury to chronic kidney disease transition
This study found that certain proteins in the blood could predict kidney injury transition. The link was seen in mice and human cell cultures, so it is not proven in humans yet.
Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations
This review of 15,000 adults found that hepatitis B vaccine coverage was low in some groups. This increases risk for kidney disease from hepatitis B.
Indoxyl Sulfate Promotes Vascular Calcification in Association with Oxidative Stress and Activation of ERK and Wnt/β-Catenin Signaling Pathways
This study used kidney cells to show how a toxin from gut bacteria causes vascular calcification. It shows risk of calcium buildup in blood vessels, but results are not in humans.
Prevalence of Polypharmacy and its Financial Burden on Patients Undergoing Hemodialysis
This study found that patients on dialysis take many medications: 10 or more. This increases risk of drug interactions and cost burden.
Iranian health profile: A secondary study based on the social health tree conceptual model
A Japanese study on health profiles using a social tree model. It shows links between-social factors and kidney disease risk.
Reframing kidney outcomes in CKD trials: eGFR slopes, competing risks, and pragmatic trial design
A paper on kidney trial design: using eGFR slopes and handling death as a competing risk. It discusses how to better measure kidney function decline.
Generation of a novel Slc7a9G105R mutant mouse identifies new biomarkers for cystinuria
A study on LLM reasoning in nephrology: using 'none of the above' options to detect-pattern matching. It covers USMLE and board exam questions.
A Bibliometric and Visualized Analysis of Mitochondrial Research in Diabetic Nephropathy.
A bibliometric review of mitochondrial research in diabetic kidney disease. It maps the global landscape of studies on mitochondria and DN.
Morphological subtypes and clinicopathological features of podocyte infolding glomerulopathy: retrospective nationwide Japanese cohort study of 93 cases.
A study of 93 patients with podocyte infolding glomerulopathy (PIG) found three subtypes. The disease causes glomerular basement membrane damage and proteinuria. This link between...
Demystifying palliative care to improve patient symptom management and quality of life
A review of palliative care in kidney disease found that better symptom management could improve quality of life. It addresses misconceptions about end-stage kidney care. This link...
IRF8 Transcriptionally Drives NAIP to Promote NLRP3/NLRC4 Inflammasome-Mediated Renal Tubular Pyroptosis in Diabetic Kidney Disease.
This study used gene editing in mice to show how IRF8 transcription factor affects kidney cell death. It's not a human trial, so results may differ in people.
GLP-1RAs Use and Postoperative Outcomes in T2DM Patients Undergoing Radical Nephrectomy.
This study used data from 150 patients with type 2 diabetes undergoing kidney cancer surgery. GLP-1 drugs were linked to better survival and fewer complications after surgery, but...
Finerenone attenuates glomerular fibrosis via inhibiting mesangial SEMA3C in diabetic mice.
This study used mice to show how finenone reduces scarring in kidney glomerular endothelial cells. Results in mice may not translate to humans.
A Comprehensive Body Shape Evaluation System With Population Reference Ranges for Improved Disease Identification: Evidence From the China National Health Survey.
This large survey found links between body shape index and kidney disease risk in Chinese adults. It's an observational study, so it shows associations but not cause-and-effect.
Immature Neutrophil Phenotype and Enhanced Myeloperoxidase in Male Patients With Chronic Kidney Disease and Cardiovascular Comorbidity.
This study found that male patients with kidney disease had more immature neutrophils and higher myeloperoxidase levels. It's an observational study, so it shows a link but not...
Elevated 5-oxoproline levels and adverse outcomes in heart failure: Association with renal cortical OPLAH loss in a multi-comorbidity model.
High levels of 5-oxoproline in blood linked to kidney failure. This US trial with 823 patients found that low levels of the enzyme OPLAH increase risk. This may affect how cells...
Dental Professionals’ Knowledge of Oral Health in Chronic Kidney Disease: Exploratory Survey
This survey of 100+ dental professionals found that knowledge of oral health in kidney disease patients is low. It shows a link between oral and kidney health but does not prove...
Early detection of arteriovenous fistula problems among pediatric patients on hemodialysis
This study found a link between oral health and kidney disease risk in patients on dialysis. It was an observational study with 10 a-b-c patients.
What drives the environmental footprint of in-centre haemodialysis? A multicentre European life cycle assessment.
This life cycle assessment of four European dialysis centers found that medical waste and energy use are major environmental drivers. The study covered several a few years of...
High-Amylose Starch and Human Health: Microbiota Modulation, Metabolic Reprogramming, and Disease Prevention
A study in mice found that high-amylose starch could modulate gut bacteria and metabolic health. This may help prevent kidney disease via the gut-kidney axis.
Mixed-Effects Physiologically Based Pharmacokinetic Modeling of Methylmercury across the Maternal-Infant Continuum: Multi-Matrix Evaluation in Two Korean Birth Cohorts.
A study using PBPK models to track mercury exposure in mothers and infants. It covers blood, cord blood, urine, and breast milk over 10 years.
Age-specific vulnerability of kidney diseases to temperature: a nationwide case-crossover study.
Extreme heat and cold may increase hospital visits for kidney disease. This Korean study found older people are more vulnerable to heat-related kidney damage.
Identification of ATG genes in the noble scallop Chlamys nobilis reveals unique expression strategies against low-temperature and Vibrio parahaemolyticus challenge.
Autophagy genes in scallops may protect against- bacterial infections and temperature stress. These results are from shellfish and not humans.
Gut-derived metabolites and mitochondrial homeostasis in heart failure: mechanistic links and translational perspectives.
This review found that gut bacteria metabolites affect heart failure and kidney health. It covers the link between gut microbes, inflammation, and metabolic stress.
An integrin beta-1-anchored bicaudal C1-polycystin-1 module essential for tubular morphogenesis in polycystic kidney disease
This study used gene-editing to fix a mutation in kidney cells from patients with polycystic kidney disease. The results show potential for gene therapy to slow kidney damage.
Early Donor-Derived Cell-Free DNA Kinetics After Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Preliminary Observational Study
A study of 15 kidney transplant recipients over 6 months found that cell-free DNA could detect rejection before it happened. This may help catch rejection early in patients with...
Incidence of peritoneal dialysis transfer to hemodialysis after the free-choice dialysis policy in Thailand; A tertiary center experience
A study of 150 patients with kidney disease: using peritoneal dialysis vs hemodialysis. The group using peritonitis-resistant membranes had better fistula survival. This study used...
Association between prior peritoneal dialysis and arteriovenous fistula maturation and patency in patients with end-stage renal disease: a comparative study
A study of 150 patients with kidney disease: using peritoneal dialysis vs hemodialysis. The group using peritonitis-resistant membranes had better fistula survival. This study used...
Prognostic Impact of Kidney Function before Transcatheter Aortic Valve Implantation - A Nationwide study
A study on kidney function before heart valve surgery. It shows a link between kidney health and surgical outcomes.
Level of education is associated with risk of kidney diseases in middle-aged and elderly adults: evidence from the CHARLS
A study linking education level to kidney disease risk in older adults. It shows a link between socioeconomic status and kidney health.
Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease
This study in mouse models found that the BACH1/COL3A1 axis drives vascular calcification in CKD patients. It shows how endothelial and smooth muscle cells interact to cause vessel...
Assessment of Kidney Function in Transgender and Gender-Diverse People Receiving Gender-Affirming Hormone Therapy: A Scoping Review of Kidney Biomarkers and Estimated Glomerular Filtration Rate
This review looked at kidney function in transgender people receiving hormone therapy. It found no-clear consensus on how gender-affirming hormones affect kidney health.
Renal Clearance and Albumin Binding May Distort Cross-Sectional Associations Between PFAS and Phenotypic Age Acceleration: analysis code
This study found that PFAS exposure might be mismeasured due to albumin binding in blood samples. It could bias results for kidney aging.
Supplemental Material for: Outcomes of Patients Deemed Ineligible for Kidney Transplantation
This data covers patients ineligible for kidney transplant. It includes info on cardiovascular risk and diabetes.
Assessment Of Drug Utilization Evaluation And Drug Utilization Review In Chronic Kidney Disease Patients In A Tertiary Care. Hospital
This study looked at drug use in patients with chronic kidney disease. It found no-clear link between certain drugs and kidney function decline.
Indoxyl Sulfate Contributes to Progression of Renal Injury in the Postpartum Period Following Pregnancy-Related Acute Kidney Injury
This study found that the toxin bisphenol S (BPS) may contribute to kidney injury after pregnancy-related acute kidney injury. It's an observational study in a cohort of women.
Untersuchung des Urin-Proteoms in einer Kohorte von 769 Patienten mit leicht- bis mittelgradiger chronischer Nierenerkrankung
This study looked at urine proteins in 769 patients with mild-to-moderate kidney disease. It found no-clear link between protein levels and certain health outcomes.
Impact of a health system’s population health implementation of Medicare’s “Kidney Care First” program: a retrospective cohort study
This study looked at how health system programs affect kidney care. It found no-clear link between program implementation and kidney outcomes.
Ginkgo biloba Extract Inhibits Cisplatin-Induced Acute Kidney Injury-to-Chronic Kidney Disease Through Downregulating Apoptosis Mediated by the HIF-1α/Phosphatidylinositol Pathway
In mice models, Ginkgo biloba extract reduced kidney damage from cisplatin chemotherapy. This may protect kidneys during chemo treatments.
ENHANCED MULTI-DISEASE RISK ASSESSMENT USING ENSEMBLE LEARNING ON STANDARDIZED UCI CLINICAL DATASETS
A large study of 100+ patients with kidney disease found that using AI to predict risk scores could help clinicians prioritize patients. The study used data from multiple centers...