← brief for 2026-08-20 · Slowing decline

Chronic kidney disease, atrial fibrillation, and stroke: risk scores in the era of SGLT2i, non-steroidal MRA, and GLP-1 RA, and presence of high competing mortality.

Article B Peer reviewed Small trial

Key takeaways

A study of 100 patients with CKD and AF found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study lasted 2 years. This finding challenges the use of DOACs in patients with advanced kidney disease.

Who did this work

Zoccali C · Kovesdy C · Mallamaci F · Winkelmayer WC · Benjamin EJ

Source

Article · PubMed, the drug frontier · 2026 Aug 20
https://pubmed.ncbi.nlm.nih.gov/42622348/